Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2023-01-20 DOI:10.1146/annurev-pharmtox-051922-113350
Magdaléna Krausová, Dominik Braun, Tina Buerki-Thurnherr, Claudia Gundacker, Eva Schernhammer, Lukas Wisgrill, Benedikt Warth
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引用次数: 10

Abstract

Early human life is considered a critical window of susceptibility to external exposures. Infants are exposed to a multitude of environmental factors, collectively referred to as the exposome. The chemical exposome can be summarized as the sum of all xenobiotics that humans are exposed to throughout a lifetime. We review different exposure classes and routes that impact fetal and infant metabolism and the potential toxicological role of mixture effects. We also discuss the progress in human biomonitoring and present possiblemodels for studying maternal-fetal transfer. Data gaps on prenatal and infant exposure to xenobiotic mixtures are identified and include natural biotoxins, in addition to commonly reported synthetic toxicants, to obtain a more holistic assessment of the chemical exposome. We highlight the lack of large-scale studies covering a broad range of xenobiotics. Several recommendations to advance our understanding of the early-life chemical exposome and the subsequent impact on health outcomes are proposed.

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了解胎儿发育和幼儿期化学物质暴露:综述。
人类的早期生活被认为是对外界暴露敏感的关键时期。婴儿暴露于多种环境因素,统称为暴露物。化学物质暴露量可以概括为人类一生中接触到的所有外源性物质的总和。我们回顾了影响胎儿和婴儿代谢的不同暴露类别和途径以及混合效应的潜在毒理学作用。我们还讨论了人类生物监测的进展,并提出了研究母胎移植的可能模型。确定了产前和婴儿接触外源性混合物的数据缺口,除了通常报告的合成毒物外,还包括天然生物毒素,以便对化学品接触进行更全面的评估。我们强调缺乏涵盖广泛的外源性药物的大规模研究。提出了几项建议,以增进我们对生命早期化学接触及其对健康结果的后续影响的理解。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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