Improving the Biological Properties of UHMWPE Biocomposite for Orthopedic Applications.

IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS International Journal of Biomaterials Pub Date : 2023-01-01 DOI:10.1155/2023/4219841
Tamara R Kadhim, Jawad K Oleiwi, Qahtan A Hamad
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引用次数: 1

Abstract

Bone plates are essential for bone fracture healing because they modify the biomechanical microenvironment at the fracture site to provide the necessary mechanical fixation for fracture fragments. The objective of this study was to determine cell availability, antibacterial activity, and wettability through a contact angle test. However, biocomposites that involve UHMWPE reinforced with n-HA and n-TiO2 particles at different fractions (0, 1.5, 2.5, 3.5, and 4.5%) and 5% from carbon and Kevlar fibers were fabricated by hot pressing technique. In vitro studies revealed good cell viability on the surface of the hybrid biocomposite even after 72 hr. The UHMEPE nanocomposite reinforced with carbon showed better cell attachment for fibroblasts than other UHMWPE nanocomposite materials reinforced with Kevlar fiber. The results of the contact angle measurements indicated that the incorporation of nanoparticles and the fiber reinforcement increased the wettability due to the hydrophilic character of nanobiocomposite, and also (UHMWPE-4.5% wt. TiO2-CF) biocomposite was the best wettability (∼48% as compared to neat UHMWPE). Antibacterial experiments involving Gram-positive bacteria, Staphylococcus aureus, confirm excellent bactericidal property for (UHMWPE-4.5% wt. TiO2-CF) biocomposite. Thermal analysis of the produced nanocomposites revealed that they had higher melting and crystallinity temperatures than pure UHMWPE.

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提高超高分子量聚乙烯生物复合材料在骨科领域的生物学性能。
骨板对骨折愈合至关重要,因为它们可以改变骨折部位的生物力学微环境,为骨折碎片提供必要的机械固定。本研究的目的是通过接触角测试确定细胞可用性、抗菌活性和润湿性。然而,通过热压技术制备了由碳和凯夫拉尔纤维以不同分数(0、1.5、2.5、3.5和4.5%)和5%的n-HA和n-TiO2颗粒增强的超高分子量聚乙烯生物复合材料。体外研究表明,即使在72小时后,混合生物复合材料表面仍具有良好的细胞活力。碳增强UHMEPE纳米复合材料对成纤维细胞的附着性优于其他凯夫拉纤维增强UHMWPE纳米复合材料。接触角测量结果表明,纳米颗粒和纤维增强剂的掺入增加了纳米生物复合材料的亲水性,并且(UHMWPE-4.5% wt. TiO2-CF)生物复合材料的润湿性最好(与纯UHMWPE相比,润湿性为48%)。对革兰氏阳性菌金黄色葡萄球菌的抑菌实验证实(UHMWPE-4.5% wt. TiO2-CF)生物复合材料具有优异的杀菌性能。对制备的纳米复合材料的热分析表明,它们比纯超高分子量聚乙烯具有更高的熔融温度和结晶度。
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来源期刊
International Journal of Biomaterials
International Journal of Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
4.30
自引率
3.20%
发文量
50
审稿时长
21 weeks
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