Similar grey matter abnormalities in 22q11.2DS and chronic schizophrenia: a voxel-based morphometry study.

IF 1 4区医学 Q4 PSYCHIATRY Rivista di psichiatria Pub Date : 2023-01-01 DOI:10.1708/3964.39426

Marianna Frascarelli, Tommaso Accinni, Antonino Buzzanca, Carlo Di Bonaventura, Martina Fanella, Carolina Putotto, Bruno Marino, Massimo Pasquini, Massimo Biondi, Claudio Colonnese, Fabio Di Fabio

{"title":"Similar grey matter abnormalities in 22q11.2DS and chronic schizophrenia: a voxel-based morphometry study.","authors":"Marianna Frascarelli, Tommaso Accinni, Antonino Buzzanca, Carlo Di Bonaventura, Martina Fanella, Carolina Putotto, Bruno Marino, Massimo Pasquini, Massimo Biondi, Claudio Colonnese, Fabio Di Fabio","doi":"10.1708/3964.39426","DOIUrl":null,"url":null,"abstract":"Background: The 22q11.2 Deletion Syndrome (22q11.2DS) is considered the most reliable biological model to study genetic vulnerability to schizophrenia. It appears useful to investigate neuroanatomical characteristics of people with 22q11.2DS compared to chronic schizophrenia and healthy controls.Methods: The sample consisted of 16 individuals with a diagnosis of schizophrenia for over 10 years (SCZ>10), 14 with a diagnosis for less than 10 years (SCZ≤10), 11 patients with 22q11.2DS with no diagnosis of psychotic disorder (DEL, n=11) and 19 healthy controls (HCs, n=19). Global intelligence (IQ) was evaluated for all subjects. Voxel-Based Morphometry (VBM) was employed to investigate potential differences between groups in grey matter volumes.Results: VBM located the most significant difference between SCZ and HCs in the left medial frontal gyrus, where SCZ>10 group showed a significant reduction of grey matter volume; the same cluster resulted significantly decreased in DEL group compared to HCs as well. Despite the extensive grey matter abnormalities observed in 22q11.2DS, the DEL group showed the only significant differences compared to the SCZ>10 group in the right lingual gyrus volumes.Conclusions: Despite the small sample, our study identified a common area of grey matter loss both in idiopathic schizophrenia and 22q11.2DS.","PeriodicalId":21506,"journal":{"name":"Rivista di psichiatria","volume":"58 1","pages":"10-20"},"PeriodicalIF":1.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rivista di psichiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1708/3964.39426","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The 22q11.2 Deletion Syndrome (22q11.2DS) is considered the most reliable biological model to study genetic vulnerability to schizophrenia. It appears useful to investigate neuroanatomical characteristics of people with 22q11.2DS compared to chronic schizophrenia and healthy controls.

Methods: The sample consisted of 16 individuals with a diagnosis of schizophrenia for over 10 years (SCZ>10), 14 with a diagnosis for less than 10 years (SCZ≤10), 11 patients with 22q11.2DS with no diagnosis of psychotic disorder (DEL, n=11) and 19 healthy controls (HCs, n=19). Global intelligence (IQ) was evaluated for all subjects. Voxel-Based Morphometry (VBM) was employed to investigate potential differences between groups in grey matter volumes.

Results: VBM located the most significant difference between SCZ and HCs in the left medial frontal gyrus, where SCZ>10 group showed a significant reduction of grey matter volume; the same cluster resulted significantly decreased in DEL group compared to HCs as well. Despite the extensive grey matter abnormalities observed in 22q11.2DS, the DEL group showed the only significant differences compared to the SCZ>10 group in the right lingual gyrus volumes.

Conclusions: Despite the small sample, our study identified a common area of grey matter loss both in idiopathic schizophrenia and 22q11.2DS.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

22q11.2DS和慢性精神分裂症相似的灰质异常:基于体素的形态学研究

背景:22q11.2缺失综合征(22q11.2 ds)被认为是研究精神分裂症遗传易感性最可靠的生物学模型。研究22q11.2DS患者与慢性精神分裂症和健康对照者的神经解剖学特征似乎是有用的。方法:16例精神分裂症诊断超过10年(SCZ>10)， 14例诊断小于10年(SCZ≤10)，11例22q11.2DS未诊断为精神障碍(DEL, n=11)， 19例健康对照(hc, n=19)。对所有受试者的整体智力(IQ)进行评估。采用基于体素的形态测量法(VBM)研究各组灰质体积的潜在差异。结果:VBM发现SCZ组与hc组在左侧额内回区差异最显著，SCZ>10组脑灰质体积显著减少;与hc组相比，DEL组同一簇也显著降低。尽管在22q11.2DS中观察到广泛的灰质异常，但与SCZ>10组相比，DEL组在右侧舌回体积上显示出唯一的显著差异。结论:尽管样本量小，但我们的研究确定了特发性精神分裂症和22q11.2DS中灰质丢失的共同区域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Rivista di psichiatria 医学-精神病学

CiteScore

5.00

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gli interessi della rivista riguardano l’approfondimento delle interazioni tra mente e malattia, la validazione e la discussione dei nuovi strumenti e parametri di classificazione diagnostica, la verifica delle prospettive terapeutiche farmacologiche e non.