Natriuretic Peptide Receptors (NPRs) as a Potential Target for the Treatment of Heart Failure.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2023-10-01 Epub Date: 2023-09-15 DOI:10.1007/s11897-023-00628-8

Adamu T Bekele

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Abstract

Purpose of review: Heart failure is defined as a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. The natriuretic peptide is known to exert its biological action on the kidney, heart, blood vessels, renin-angiotensin system, autonomous nervous system, and central nervous system. The natriuretic peptide-natriuretic receptor system plays an important role in the regulation of blood pressure and body fluid volume through its pleiotropic effects.

Recent findings: The clinical and animal studies suggest that natriuretic peptide-natriuretic receptors are important targets for the treatment of heart failure and other cardiovascular diseases. Even though attempts targeting natriuretic peptide receptors are underway for heart failure treatment, they seem insufficient despite the receptor systems' potential. This review summarizes natriuretic peptide-natriuretic receptor system's physiological actions and potential target for the treatment of heart failure. Natriuretic peptides play multiple roles in different parts of the body, almost all of the activities related to this receptor system appear to have the potential to be harnessed to treat heart failure or symptoms associated with heart failure.

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利钠肽受体（NPRs）作为治疗心力衰竭的潜在靶点。

综述目的：心力衰竭被定义为一种复杂的临床综合征，由心室充盈或血液喷射的任何结构或功能损伤引起。众所周知，钠尿肽对肾脏、心脏、血管、肾素-血管紧张素系统、自主神经系统和中枢神经系统发挥生物作用。利钠肽-利钠肽受体系统通过其多效性作用在调节血压和体液量方面发挥着重要作用。最近的发现：临床和动物研究表明，利钠肽利钠肽受体是治疗心力衰竭和其他心血管疾病的重要靶点。尽管针对利钠肽受体的治疗心力衰竭的尝试正在进行中，但尽管受体系统具有潜力，但它们似乎还不够。本文综述了利钠肽-利钠肽受体系统的生理作用和治疗心力衰竭的潜在靶点。利钠肽在身体的不同部位发挥着多种作用，几乎所有与该受体系统相关的活动都有可能被用于治疗心力衰竭或与心力衰竭相关的症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Heart Failure Reports Medicine-Emergency Medicine

CiteScore

5.30

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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