Microfluidic Co-culture Platforms for Studying Osteocyte Regulation of Other Cell Types under Dynamic Mechanical Stimulation.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Current Osteoporosis Reports Pub Date : 2022-12-01 DOI:10.1007/s11914-022-00748-5
Chun-Yu Lin, Xin Song, Kimberly Seaman, Lidan You
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引用次数: 2

Abstract

Purpose of review: Osteocytes are the most abundant cell type in bone. These unique cells act primarily as mechanosensors and play crucial roles in the functional adaptation of bone tissue. This review aims to summarize the recent microfluidic studies on mechanically stimulated osteocytes in regulating other cell types.

Recent findings: Microfluidics is a powerful technology that has been widely employed in recent years. With the advantages of microfluidic platforms, researchers can mimic multicellular environments and integrate dynamic systems to study osteocyte regulation under mechanical stimulation. Microfluidic platforms have been developed to investigate mechanically stimulated osteocytes in the direct regulation of multiple cell types, including osteoclasts, osteoblasts, and cancer cells, and in the indirect regulation of cancer cells via endothelial cells. Overall, these microfluidic studies foster the development of treatment approaches targeting osteocytes under mechanical stimulation.

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动态机械刺激下其他细胞类型骨细胞调控的微流体共培养平台。
综述目的:骨细胞是骨中最丰富的细胞类型。这些独特的细胞主要作为机械传感器,在骨组织的功能适应中起着至关重要的作用。本文综述了近年来机械刺激骨细胞调节其他细胞类型的微流控研究进展。微流控技术是近年来广泛应用的一项强大的技术。利用微流控平台的优势,研究人员可以模拟多细胞环境并整合动态系统来研究机械刺激下骨细胞的调节。微流控平台已被开发用于研究机械刺激的骨细胞对多种细胞类型的直接调节,包括破骨细胞、成骨细胞和癌细胞,以及通过内皮细胞对癌细胞的间接调节。总的来说,这些微流体研究促进了机械刺激下针对骨细胞的治疗方法的发展。
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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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