Anatomical biology guides a search for nutrients for the aging brain

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Aspects of Medicine Pub Date : 2023-02-01 DOI:10.1016/j.mam.2022.101154

Vincenzo Lauriola , Adam M. Brickman , Richard P. Sloan , Scott A. Small

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引用次数: 2

Abstract

Considerable evidence has established the importance of specific nutrients that have been found vital for the developing brain. We hypothesize that in a similar manner there should be nutrients vital to the aging brain and that based on aging's distinct pathophysiology they should be different than those essential to development. Specific brain networks that govern cognition are particularly vulnerable to the aging process, resulting in what is referred to as ‘cognitive aging’. Common late-life disorders, however, such as Alzheimer's disease also target these same brain networks. Studies have disambiguated cognitive aging from late-life disease by isolating regions and biological pathways within each network differentially linked to one or the other. This anatomical biology anchors a framework to identify nutrients and/or dietary bioactives relevant to cognitive aging whose utility is illustrated via a decades-long research program into how dietary bioactive flavanols benefit the brain. As we are living longer in cognitively more demanding lives, the framework's ultimate goal is to generate specific dietary recommendations that will fortify our mind for its golden years.

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解剖学生物学指导寻找衰老大脑的营养物质

大量证据已经证实了特定营养素的重要性，这些营养素对发育中的大脑至关重要。我们假设，以类似的方式，应该有对衰老大脑至关重要的营养物质，并且基于衰老独特的病理生理学，它们应该与发育所必需的营养物质不同。控制认知的特定大脑网络特别容易受到衰老过程的影响，从而导致所谓的“认知衰老”。然而，常见的晚年疾病，如阿尔茨海默病，也针对这些相同的大脑网络。研究通过隔离每个网络中不同连接的区域和生物途径，消除了认知衰老与晚期疾病的歧义。这一解剖生物学为识别与认知衰老相关的营养素和/或膳食生物活性奠定了基础，通过一项长达数十年的膳食生物活性黄烷醇如何有益于大脑的研究计划，可以说明其效用。随着我们在认知要求更高的生活中活得更长，该框架的最终目标是制定具体的饮食建议，为我们的黄金岁月提供营养。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.