Non-coding RNAs as Biomarkers for Survival in Colorectal Cancer Patients.

Mohammad Qasim Andrabi, Yasodha Kesavan, Satish Ramalingam
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Abstract

Colorectal cancer (CRC) has a high incidence and fatality rate worldwide. It ranks second concerning death worldwide. Cancer patients are diagnosed with the disease at a later stage due to the absence of early diagnostic methods, which leads to increased death. With the help of recent advancements in the fields of diagnosis and therapy, the development of novel methods using new targets could be helpful for the long-term survival of CRC patients when CRC is detected early. However, the prognosis for the advanced stage of CRC is abysmal. New biomarkers are emerging as promising alternatives since they can be utilized for early detection of CRC, are simple to use, and non-invasive. Non-coding RNAs (ncRNAs) have been seen to have an aberrant expression in the development of many malignancies, including CRC. In the past two decades, much research has been done on non-coding RNAs, which may be valuable as biomarkers and targets for antitumor therapy. Non-coding RNAs can be employed in detecting and treating CRC. Non-coding RNAs play an essential role in regulating gene expression. This article reviews ncRNAs and their expression levels in CRC patients that could be used as potential biomarkers. Various ncRNAs have been associated with CRC, such as microRNAs, long non-coding RNAs, circular RNAs, etc. The expression of these non-coding RNAs may provide insights into the stages of cancer and the prognosis of cancer patients and therefore proper precautionary measures can be taken to decrease cancer-related deaths.

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作为结直肠癌患者生存期生物标志物的非编码 RNA
结肠直肠癌(CRC)在全球的发病率和死亡率都很高。它在全球死亡病例中排名第二。由于缺乏早期诊断方法,癌症患者被诊断出患病的时间较晚,导致死亡人数增加。随着诊断和治疗领域的最新进展,利用新靶点开发新方法有助于早期发现 CRC 患者的长期生存。然而,晚期 CRC 的预后非常糟糕。新的生物标记物正在成为有希望的替代方法,因为它们可用于早期检测 CRC,使用简单且无创。非编码 RNA(ncRNA)在许多恶性肿瘤(包括 CRC)的发病过程中都有异常表达。在过去二十年中,人们对非编码 RNA 进行了大量研究,这些 RNA 可能是有价值的生物标志物和抗肿瘤治疗靶标。非编码 RNA 可用于检测和治疗 CRC。非编码 RNA 在调控基因表达方面发挥着重要作用。本文综述了非编码 RNA 及其在 CRC 患者中的表达水平,这些非编码 RNA 有可能成为潜在的生物标记物。有多种 ncRNA 与 CRC 相关,如 microRNA、长非编码 RNA、环状 RNA 等。这些非编码 RNA 的表达可能有助于了解癌症的分期和癌症患者的预后,从而采取适当的初步措施减少与癌症相关的死亡。
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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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