Tendon tissue engineering: An overview of biologics to promote tendon healing and repair.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-09-13 eCollection Date: 2023-01-01 DOI:10.1177/20417314231196275
Vera Citro, Marta Clerici, Aldo R Boccaccini, Giovanna Della Porta, Nicola Maffulli, Nicholas R Forsyth
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引用次数: 1

Abstract

Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion and maintaining posture. Tendon injuries, also known as tendinopathies, are becoming more common as populations age and participation in sports/leisure activities increases. The tendon has a poor ability to self-heal and regenerate given its intrinsic, constrained vascular supply and exposure to frequent, severe loading. There is a lack of understanding of the underlying pathophysiology, and it is not surprising that disorder-targeted medicines have only been partially effective at best. Recent tissue engineering approaches have emerged as a potential tool to drive tendon regeneration and healing. In this review, we investigated the physiochemical factors involved in tendon ontogeny and discussed their potential application in vitro to reproduce functional and self-renewing tendon tissue. We sought to understand whether stem cells are capable of forming tendons, how they can be directed towards the tenogenic lineage, and how their growth is regulated and monitored during the entire differentiation path. Finally, we showed recent developments in tendon tissue engineering, specifically the use of mesenchymal stem cells (MSCs), which can differentiate into tendon cells, as well as the potential role of extracellular vesicles (EVs) in tendon regeneration and their potential for use in accelerating the healing response after injury.

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肌腱组织工程:促进肌腱愈合和修复的生物制品综述。
肌腱是具有分层极化结构的致密结缔组织,对肌肉收缩力向骨骼的传递做出反应并适应,从而实现运动和保持姿势。肌腱损伤,也称为肌腱病,随着人口老龄化和参与体育/休闲活动的增加,变得越来越常见。肌腱的自我愈合和再生能力较差,因为其固有的、受限的血管供应以及暴露在频繁、严重的负荷下。人们对潜在的病理生理学缺乏了解,以疾病为靶向的药物充其量只能部分有效也就不足为奇了。最近的组织工程方法已经成为推动肌腱再生和愈合的潜在工具。在这篇综述中,我们研究了参与肌腱个体发育的理化因素,并讨论了它们在体外繁殖功能性和自我更新的肌腱组织中的潜在应用。我们试图了解干细胞是否能够形成肌腱,它们如何被引导到肌腱生成谱系,以及在整个分化过程中如何调节和监测它们的生长。最后,我们展示了肌腱组织工程的最新进展,特别是可以分化为肌腱细胞的间充质干细胞(MSCs)的使用,以及细胞外小泡(EVs)在肌腱再生中的潜在作用及其在加速损伤后愈合反应中的潜力。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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