Michael Thrull, Khaled Atasi, Lennart-Maximilian Boese, Mahmut Cakar, Ullrich Heller, Nils Jansen, Leoni-Christine Menzel, Hassan Omaimen, Katharina Theis, Damir Karacic, Diyan Dimov, Roland Coras, Randolf Klingebiel
{"title":"Transdural Skull Base Infiltration by Glioblastoma: Case Report and Review of the Literature.","authors":"Michael Thrull, Khaled Atasi, Lennart-Maximilian Boese, Mahmut Cakar, Ullrich Heller, Nils Jansen, Leoni-Christine Menzel, Hassan Omaimen, Katharina Theis, Damir Karacic, Diyan Dimov, Roland Coras, Randolf Klingebiel","doi":"10.1155/2023/4727288","DOIUrl":null,"url":null,"abstract":"<p><p>We report the rare occurrence of a temporal glioblastoma multiforme (GBM) showing transdural tumor extension into adjacent mastoid cells. As the dura mater provides a barrier to intraaxial tumors, GBM seldom penetrates into the skull base, even though it is a high-grade astrocytoma with a tendency to spread. Yet, some mechanisms of GBM-induced skull invasion have been identified, making this entity a very rare but nonetheless relevant differential diagnosis in otherwise ambiguous cases of an intracerebral tumor extending into the skull base. In addition, imaging markers that may assist in distinguishing extra- from intraaxial tumor infiltration of the temporal bone are described.</p>","PeriodicalId":45872,"journal":{"name":"Case Reports in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891834/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Otolaryngology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/4727288","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We report the rare occurrence of a temporal glioblastoma multiforme (GBM) showing transdural tumor extension into adjacent mastoid cells. As the dura mater provides a barrier to intraaxial tumors, GBM seldom penetrates into the skull base, even though it is a high-grade astrocytoma with a tendency to spread. Yet, some mechanisms of GBM-induced skull invasion have been identified, making this entity a very rare but nonetheless relevant differential diagnosis in otherwise ambiguous cases of an intracerebral tumor extending into the skull base. In addition, imaging markers that may assist in distinguishing extra- from intraaxial tumor infiltration of the temporal bone are described.