Investigation of the gait parameters after donepezil treatment in patients with alzheimer' s disease.

IF 1.5 4区心理学 Q4 CLINICAL NEUROLOGY Applied Neuropsychology-Adult Pub Date : 2025-03-01 Epub Date: 2023-02-06 DOI:10.1080/23279095.2023.2172681

Ozlem Bizpinar, Halil Onder

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Abstract

Introduction: Clinical studies remark that gait disturbance is common in patients with Alzheimer's disease (AD). However, the treatment response of gait disturbance in those patients may constitute a more interesting issue that is rarely addressed.

Methods: In this prospective, interventional study, we included 14 consecutive patients with a new diagnosis of AD. Basal gait analysis was performed using a 'Gait Analyzer' program that was uploaded to a mobile phone. The gait parameters including Step time (ST), step length (SL), step number (SN), gait velocity (GV), and cadence were measured. Afterward, donepezil 5 mg daily was initiated, and the re-assessments were re-performed 8 weeks after the treatment.

Results: The mean age was 71.78 ± 5.02 (F/M = 8/6). The evaluations after the donepezil treatment showed that there was a significant improvement in the SN (p = 0.021) and SL (p = 0.001) in comparison to the basal evaluations. The repeated analysis in the subgroup of early-stage AD subjects (n = 10) yielded that there were significant improvements in SN (p = 0.003), SL (p = 0.005), and cadence (p = 0.026) after treatment.

Conclusions: Our results support the efficiency of cholinergic treatment in gait functions in AD subjects.

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阿尔茨海默病患者接受多奈哌齐治疗后步态参数的研究。

简介临床研究表明，步态障碍在阿尔茨海默病患者（AD）中很常见。然而，这些患者对步态障碍的治疗反应可能是一个更有趣的问题，却很少有人关注：在这项前瞻性干预研究中，我们连续纳入了 14 名新诊断为阿尔茨海默病患者。我们使用 "步态分析仪 "程序进行了基础步态分析，并将其上传到手机上。步态参数包括步时（ST）、步长（SL）、步数（SN）、步速（GV）和步幅。之后，每天服用多奈哌齐 5 毫克，治疗 8 周后重新进行评估：平均年龄为 71.78 ± 5.02（女/男 = 8/6）。多奈哌齐治疗后的评估显示，与基础评估相比，SN（p = 0.021）和SL（p = 0.001）有显著改善。对早期AD受试者亚组（n = 10）的重复分析显示，治疗后SN（p = 0.003）、SL（p = 0.005）和步调（p = 0.026）均有明显改善：结论：我们的研究结果表明，胆碱能治疗可有效改善AD患者的步态功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.