Enantioselective Behavior of Flumequine Enantiomers and Metabolites' Identification in Sediment.

IF 2.3 3区 化学 Q3 CHEMISTRY, ANALYTICAL Journal of Analytical Methods in Chemistry Pub Date : 2022-12-02 eCollection Date: 2022-01-01 DOI:10.1155/2022/2184024
Moyong Xue, Xu Gu, Yuchang Qin, Junguo Li, Qingshi Meng, Ming Jia
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Abstract

The enantioselective adsorption, degradation, and transformation of flumequine (FLU) enantiomers in sediment were investigated to elucidate the enantioselective environmental behaviors. The results of adsorption test showed that stereoselective differences of FLU enantiomers in sediment samples and the adsorbing capacity of S-(-)-FLU and R-(+)-FLU are higher than the racemate, and the pH values of the sediment determined the adsorption capacity. Enantioselective degradation behaviors were found under nonsterilized conditions and followed pseudo-first-order kinetic. The R-(+)-FLU was preferentially degraded, and there was significant enantioselectivity of the degradation of FLU. It can be concluded that the microorganism was the main reason for the stereoselective degradation in sediments. The physicochemical property of sediments, such as pH value and organic matter content, can affect the degradation rate of FLU. In addition, the process of transformation of FLU enantiomers in water-sediment system had enantioselective behavior, and R-(+)-FLU was preferential transformed. Meanwhile, the main metabolites of FLU in the sediment were decarboxylate and dihydroxylation products. This study contributes the evidence of comprehensively assessing the fate and risk of chiral FLU antibiotic and enantioselective behavior in the environment.

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沉积物中氟苯喹对映体的对映选择行为和代谢物的鉴定
研究了氟甲喹对映体在沉积物中的对映选择性吸附、降解和转化,以阐明其对映选择性环境行为。吸附试验结果表明,FLU对映体在沉积物样品中存在立体选择性差异,S-(-)-FLU和R-(+)-FLU的吸附能力高于外消旋体,沉积物的pH值决定了吸附能力。在非灭菌条件下,S-(-)-FLU和R-(+)-FLU的对映体选择性降解行为遵循假一阶动力学。R-(+)-FLU优先被降解,FLU的降解具有显著的对映体选择性。由此可以得出结论,微生物是造成沉积物中立体选择性降解的主要原因。沉积物的物理化学性质(如 pH 值和有机物含量)会影响 FLU 的降解速率。此外,FLU对映体在水-沉积物体系中的转化过程具有对映选择性,R-(+)-FLU优先转化。同时,FLU在沉积物中的主要代谢产物为脱羧产物和二羟化产物。该研究为全面评估手性FLU抗生素在环境中的归宿和风险以及对映选择行为提供了证据。
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来源期刊
Journal of Analytical Methods in Chemistry
Journal of Analytical Methods in Chemistry CHEMISTRY, ANALYTICAL-ENGINEERING, CIVIL
CiteScore
4.80
自引率
3.80%
发文量
79
审稿时长
6-12 weeks
期刊介绍: Journal of Analytical Methods in Chemistry publishes papers reporting methods and instrumentation for chemical analysis, and their application to real-world problems. Articles may be either practical or theoretical. Subject areas include (but are by no means limited to): Separation Spectroscopy Mass spectrometry Chromatography Analytical Sample Preparation Electrochemical analysis Hyphenated techniques Data processing As well as original research, Journal of Analytical Methods in Chemistry also publishes focused review articles that examine the state of the art, identify emerging trends, and suggest future directions for developing fields.
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