In-vivo and in vitro assessments of the radioprotective potential natural and chemical compounds: a review.

IF 2.1 4区医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2023-01-01 DOI:10.1080/09553002.2022.2078007

Anis Javadi, Mohammad Reza Nikhbakht, Javad Ghasemian Yadegari, Auob Rustamzadeh, Mohsen Mohammadi, Alireza Shirazinejad, Saleh Azadbakht, Zahra Abdi

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引用次数: 2

Abstract

Purpose: The study of the radioactive role of natural and chemical substances on human and animal studies has been the subject of research by some researchers. Therefore, the review of some of the past and current studies conducted in this field, can provide helpful information to elucidate of the importance of radioprotective components in reducing radiation exposure side effects.

Methods: The authors search for keywords including In vitro, In vivo, Radioprotective, Ionizing radiation, and Vitamin in ScienceDirect, Scopus, Pubmed, and Google Scholar databases to access previously published articles and search for more reference articles on the role of radioprotective materials from natural and chemical compounds.

Results: Radiation exposure can produce reactive oxygen species (ROS) in the body, however most of which are eliminated by the body's natural mechanisms, but when the body's antioxidant systems do not have enough ability to neutralize free radicals, oxidative stress occurs, which causes damage to DNA and body tissues. Therefore, it is necessary use of alternative substances that reduce and inhibit free radicals.

Conclusion: In general, recommended that antioxidant component(s) can be protect tissue damages in humans or animals, due to the their ability to scavenge free radicals generated by ionizing radiation.

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天然化合物和化学化合物辐射防护潜力的体内和体外评估:综述。

目的:研究天然物质和化学物质对人体和动物的放射性作用一直是一些研究人员研究的课题。因此，回顾过去和目前在这一领域进行的一些研究，可以提供有用的信息来阐明辐射防护成分在减少辐射暴露副作用方面的重要性。方法:作者在ScienceDirect、Scopus、Pubmed和Google Scholar数据库中搜索关键词In vitro, In vivo, Radioprotective, Ionizing radiation, and Vitamin，获取先前发表的文章，并搜索更多关于天然和化学化合物中放射性防护材料作用的参考文章。结果:辐射暴露可在体内产生活性氧(ROS)，但其中大部分被机体的自然机制所消除，但当机体的抗氧化系统没有足够的能力来中和自由基时，就会发生氧化应激，从而导致DNA和机体组织的损伤。因此，有必要使用减少和抑制自由基的替代物质。结论:一般来说，推荐抗氧化成分可以保护人体或动物的组织损伤，因为它们具有清除电离辐射产生的自由基的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Biology 医学-核科学技术

CiteScore

5.00

自引率

11.50%

发文量

142

审稿时长

3 months

期刊介绍： The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.