Paternal transmission of behavioural and metabolic traits induced by postnatal stress to the 5th generation in mice.

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2022-01-01 DOI:10.1093/eep/dvac024
Chiara Boscardin, Francesca Manuella, Isabelle M Mansuy
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引用次数: 1

Abstract

Life experiences and environmental conditions in childhood can change the physiology and behaviour of exposed individuals and, in some cases, of their offspring. In rodent models, stress/trauma, poor diet, and endocrine disruptors in a parent have been shown to cause phenotypes in the direct progeny, suggesting intergenerational inheritance. A few models also examined transmission to further offspring and suggested transgenerational inheritance, but such multigenerational inheritance is not well characterized. Our previous work on a mouse model of early postnatal stress showed that behaviour and metabolism are altered in the offspring of exposed males up to the 4th generation in the patriline and up to the 2nd generation in the matriline. The present study examined if symptoms can be transmitted beyond the 4th generation in the patriline. Analyses of the 5th and 6th generations of mice revealed that altered risk-taking and glucose regulation caused by postnatal stress are still manifested in the 5th generation but are attenuated in the 6th generation. Some of the symptoms are expressed in both males and females, but some are sex-dependent and sometimes opposite. These results indicate that postnatal trauma can affect behaviour and metabolism over many generations, suggesting epigenetic mechanisms of transmission.

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出生后应激诱导小鼠行为和代谢性状的父系遗传至第5代。
童年时期的生活经历和环境条件可以改变接触者的生理和行为,在某些情况下,还可以改变他们的后代。在啮齿动物模型中,父母一方的压力/创伤、不良饮食和内分泌干扰物已被证明会导致直系后代的表型,这表明代际遗传。一些模型还研究了进一步的后代的遗传,并提出了跨代遗传,但这种多代遗传并没有很好地表征。我们之前对早期产后应激小鼠模型的研究表明,暴露在这种环境下的雄性小鼠的后代行为和代谢会发生改变,一直到父系第4代,一直到母系第2代。本研究调查了症状是否可以在父系中传播超过第四代。对第5代和第6代小鼠的分析显示,产后应激引起的冒险和葡萄糖调节的改变在第5代中仍然表现出来,但在第6代中有所减弱。有些症状在男性和女性中都有表现,但有些症状是性别依赖的,有时是相反的。这些结果表明,产后创伤可以影响许多代人的行为和代谢,这表明了表观遗传机制的传播。
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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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