Bioproduction of porphyrins, phycobilins, and their proteins using microbial cell factories: engineering, metabolic regulations, challenges, and perspectives.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-12 DOI:10.1080/07388551.2023.2168512
Young Jin Ko, Myeong-Eun Lee, Byeong-Hyeon Cho, Minhye Kim, Jeong Eun Hyeon, Joo Hee Han, Sung Ok Han
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Abstract

Porphyrins, phycobilins, and their proteins have abundant π-electrons and strongly absorb visible light, some of which bind a metal ion in the center. Because of the structural and optical properties, they not only play critical roles as an essential component in natural systems but also have attracted much attention as a high value specialty chemical in various fields, including renewable energy, cosmetics, medicines, and foods. However, their commercial application seems to be still limited because the market price of porphyrins and phycobilins is generally expensive to apply them easily. Furthermore, their petroleum-based chemical synthesis is energy-intensive and emits a pollutant. Recently, to replace petroleum-based production, many studies on the bioproduction of metalloporphyrins, including Zn-porphyrin, Co-porphyrin, and heme, porphyrin derivatives including chlorophyll, biliverdin, and phycobilins, and their proteins including hemoproteins, phycobiliproteins, and phytochromes from renewable carbon sources using microbial cell factories have been reported. This review outlines recent advances in the bioproduction of porphyrins, phycobilins, and their proteins using microbial cell factories developed by various microbial biotechnology techniques, provides well-organized information on metabolic regulations of the porphyrin metabolism, and then critically discusses challenges and future perspectives. Through these, it is expected to be able to achieve possible solutions and insights and to develop an outstanding platform to be applied to the industry in future research.

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利用微生物细胞工厂进行卟啉、藻青素及其蛋白质的生物生产:工程、代谢调节、挑战和前景。
卟啉、藻蓝蛋白及其蛋白质具有丰富的π电子,能强烈吸收可见光,其中一些还能在中心结合金属离子。由于其结构和光学特性,它们不仅是自然系统中的重要组成部分,而且在可再生能源、化妆品、医药和食品等多个领域作为一种高价值的特种化学品而备受关注。然而,由于卟啉和藻青素的市场价格普遍昂贵,难以轻易应用,因此它们的商业应用似乎仍然有限。此外,以石油为基础的化学合成法不仅耗费大量能源,还会排放污染物。最近,为了替代石油生产,许多关于利用微生物细胞工厂从可再生碳源生物生产金属卟啉(包括锌卟啉、钴卟啉和血红素)、卟啉衍生物(包括叶绿素、胆绿素和藻蓝蛋白)及其蛋白质(包括血蛋白、藻蓝蛋白和植物色素)的研究都有报道。本综述概述了利用各种微生物生物技术开发的微生物细胞工厂生物生产卟啉、藻蓝蛋白及其蛋白质的最新进展,提供了有关卟啉代谢调控的条理清晰的信息,然后批判性地讨论了面临的挑战和未来展望。通过这些,该研究有望获得可能的解决方案和见解,并开发出一个优秀的平台,在未来的研究中应用于工业领域。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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