The Infected Lungs and Brain Interface in COVID-19: The Impact on Cognitive Function.

IF 2.2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2022-01-01 DOI:10.1159/000526653

Larissa Joaquim, Amanda Della Giustina, Richard Simon Machado, Kiuanne Lino Lobo Metzker, Sandra Bonfante, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Fabricia Petronilho

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引用次数: 2

Abstract

Many coronavirus disease 2019 (COVID-19)-recovered patients report signs and symptoms and are experiencing neurological, psychiatric, and cognitive problems. However, the exact prevalence and outcome of cognitive sequelae is unclear. Even though the severe acute respiratory syndrome coronavirus 2 has target brain cells through binding to angiotensin-converting enzyme 2 (ACE2) receptor in acute infection, several studies indicate the absence of the virus in the brain of many COVID-19 patients who developed neurological disorders. Thus, the COVID-19 mechanisms for stimulating cognitive dysfunction may include neuroinflammation, which is mediated by a sustained systemic inflammation, a disrupted brain barrier, and severe glial reactiveness, especially within the limbic system. This review explores the interplay of infected lungs and brain in COVID-19 and its impact on the cognitive function.

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COVID-19感染的肺和脑界面:对认知功能的影响

许多2019冠状病毒病(COVID-19)康复的患者报告了体征和症状，并出现了神经、精神和认知问题。然而，认知后遗症的确切患病率和结果尚不清楚。尽管在急性感染中，严重急性呼吸综合征冠状病毒2通过与血管紧张素转换酶2 (ACE2)受体结合而靶向脑细胞，但一些研究表明，许多出现神经系统疾病的COVID-19患者的大脑中没有病毒。因此，COVID-19刺激认知功能障碍的机制可能包括神经炎症，这是由持续的全身性炎症、脑屏障破坏和严重的神经胶质反应介导的，特别是在边缘系统内。本文探讨了COVID-19感染的肺和脑的相互作用及其对认知功能的影响。

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来源期刊

Neuroimmunomodulation 医学-免疫学

CiteScore

3.60

自引率

4.20%

发文量

审稿时长

>12 weeks

期刊介绍： The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.