Extending the data collection from a clinical trial: The Extended Salford Lung Study research cohort.

IF 3.1 3区 医学 Q1 PRIMARY HEALTH CARE NPJ Primary Care Respiratory Medicine Pub Date : 2023-01-18 DOI:10.1038/s41533-022-00322-7
Wilhelmine Meeraus, Qinggong Fu, George Mu, Mark Fry, Lucy Frith, Jeanne M Pimenta
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Abstract

The Extended Salford Lung Study (Ext-SLS) is an extension of the Salford Lung Studies (SLS) in asthma and chronic obstructive pulmonary disease (COPD) through retrospective and prospective collection of patient-level electronic health record (EHR) data. We compared the Ext-SLS cohort with the SLS intention-to-treat populations using descriptive analyses to determine if the strengths (e.g. randomization) of the clinical trial were maintained in the new cohort. Historical and patient-reported outcome data were captured from asthma-/COPD-specific questionnaires (e.g., Asthma Control Test [ACT]/COPD Assessment Test [CAT]). The Ext-SLS included 1147 participants (n = 798, SLS asthma; n = 349, SLS COPD). Of participants answering the ACT, 39% scored <20, suggesting poorly controlled asthma. For COPD, 61% of participants answering the CAT scored ≥21, demonstrating a high disease burden. Demographic/clinical characteristics of the cohorts were similar at SLS baseline. EHR data provided a long-term view of participants' disease, and questionnaires provided information not typically captured. The Ext-SLS cohort is a valuable resource for respiratory research, and ongoing prospective data collection will add further value and ensure the Ext-SLS is an important source of patient-level information on obstructive airways disease.

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扩展临床试验的数据收集:扩展索尔福德肺研究队列研究。
扩展索尔福德肺研究(Ext-SLS)是索尔福德肺研究(SLS)在哮喘和慢性阻塞性肺疾病(COPD)方面的延伸,通过回顾性和前瞻性收集患者级电子健康记录(EHR)数据。我们使用描述性分析将Ext-SLS队列与SLS意向治疗人群进行比较,以确定临床试验的优势(例如随机化)是否在新队列中保持不变。从哮喘/COPD特异性问卷(例如哮喘控制测试[ACT]/COPD评估测试[CAT])中获取历史和患者报告的结果数据。Ext-SLS纳入1147名参与者(n = 798, SLS哮喘;n = 349, SLS COPD)。在回答ACT的参与者中,39%的人得分
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来源期刊
NPJ Primary Care Respiratory Medicine
NPJ Primary Care Respiratory Medicine PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
CiteScore
5.50
自引率
6.50%
发文量
49
审稿时长
10 weeks
期刊介绍: npj Primary Care Respiratory Medicine is an open access, online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the primary care management of respiratory and respiratory-related allergic diseases. Papers published by the journal represent important advances of significance to specialists within the fields of primary care and respiratory medicine. We are particularly interested in receiving papers in relation to the following aspects of respiratory medicine, respiratory-related allergic diseases and tobacco control: epidemiology prevention clinical care service delivery and organisation of healthcare (including implementation science) global health.
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