Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack.

IF 3 4区医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2022-11-18 eCollection Date: 2022-01-01 DOI:10.1155/2022/2219993

Zeqi Hao, Yulin Song, Yuyu Shi, Hongyu Xi, Hongqiang Zhang, Mengqi Zhao, Jiahao Yu, Lina Huang, Huayun Li

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Abstract

Objective: This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA).

Methods: A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related effective connectivity differences between individuals with TIA and HCs, the bilateral primary motor cortex (M1) was used as the regions of interest (ROIs) to perform a whole-brain Granger causality analysis (GCA). Furthermore, partial correlation was used to evaluate the relationship between GCA values and the clinical characteristics of individuals with TIA.

Results: Compared with HCs, individuals with TIA demonstrated alterations in the effective connectivity between M1 and widely distributed brain regions involved in motor, visual, auditory, and sensory integration. In addition, GCA values were significantly correlated with high- and low-density lipoprotein cholesterols in individuals with TIA.

Conclusion: This study provides important evidence for the alteration of motor-related effective connectivity in TIA, which reflects the abnormal information flow between different brain regions. This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA.

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短暂性脑缺血发作时初级运动皮层有效连接性的改变

研究目的本研究旨在探讨短暂性脑缺血发作（TIA）患者运动相关有效连接性的改变：方法：本研究共招募了 48 名 TIA 患者和 41 名年龄和性别匹配的健康对照组（HCs）。方法：本研究共招募了 48 名 TIA 患者和 41 名年龄和性别相匹配的健康对照组（HCs），使用核磁共振成像对参与者进行扫描，并收集他们的临床特征。为了研究 TIA 患者和 HC 之间与运动相关的有效连接差异，研究人员使用双侧初级运动皮层（M1）作为感兴趣区（ROI），进行全脑格兰杰因果关系分析（GCA）。此外，还利用偏相关性评估了GCA值与TIA患者临床特征之间的关系：结果：与普通人相比，TIA 患者的 M1 与广泛分布的脑区之间的有效连接发生了改变，这些脑区涉及运动、视觉、听觉和感觉整合。此外，TIA 患者的 GCA 值与高密度和低密度脂蛋白胆固醇呈显著相关：结论：本研究为 TIA 患者运动相关有效连接的改变提供了重要证据，这反映了不同脑区之间的信息流异常。这有助于进一步阐明 TIA 患者运动障碍的病理机制，并为未来 TIA 的早期诊断和干预提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity NEUROSCIENCES-

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.