Cytogenetic Influence on Prognosis in Acute Promyelocytic Leukaemia: A Cohort Study in Vietnam.

Q1 Medicine Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-12-23 DOI:10.1016/j.hemonc.2021.06.003

Minh Phuong Vu, Cuc Nhung Nguyen, Hoang Vu

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引用次数: 3

Abstract

Objective/background: To analyse the influence of chromosomal aberrations in addition to t(15;17)(q22;q21) in acute promyelocytic leukaemia (APL) on clinical characteristics and treatment outcomes.

Methods: Fifty-seven patients with new APL diagnoses underwent conventional cytogenetic analysis; fluorescence in situ hybridization for t(15;17)(q22;q21) and reverse transcriptase-polymerase chain reaction detected PML/RARα in two forms: L (length) and S (short) and accepted treatment with all-trans retinoic acid and chemotherapy. Patients with additional chromosome aberrations were designated as the complex karyotype group and were compared with patients with only t(15;17), who were designated as the simple karyotype group.

Results: Additional chromosome aberrations was observed in 18/57 patients (31.6%) at initial diagnosis. Outcome was significantly different between the simple karyotype group and the complex karyotype group for complete remission (92.3% vs. 66.7% respectively, p = .025), overall survival at 3 years (92.3% vs. 65.0%, respectively, p = .017), and progression-free survival at 3 years (81.4% vs. 44.4%, respectively, p = .024).

Conclusions: Additional chromosome aberrations had adverse effects on the prognosis in APL.

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细胞遗传学对急性早幼粒细胞白血病预后的影响:越南一项队列研究。

目的/背景:分析急性早幼粒细胞白血病(APL)患者除t(15;17)(q22;q21)外染色体畸变对临床特征和治疗结果的影响。方法:对57例新发APL患者进行常规细胞遗传学分析;荧光原位杂交t(15;17)(q22;q21)和逆转录-聚合酶链反应检测到PML/RARα以L(长)和S(短)两种形式存在，并接受全反式维甲酸和化疗治疗。附加染色体畸变的患者被指定为复杂核型组，与仅有t染色体畸变的患者进行比较(15;17)，后者被指定为简单核型组。结果:57例患者中有18例(31.6%)在初诊时出现额外的染色体畸变。简单核型组和复杂核型组在完全缓解(分别为92.3% vs. 66.7%， p = 0.025)、3年总生存率(分别为92.3% vs. 65.0%， p = 0.017)和3年无进展生存率(分别为81.4% vs. 44.4%， p = 0.024)方面的结果有显著差异。结论:附加的染色体畸变对APL患者的预后有不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology/ Oncology and Stem Cell Therapy Medicine-Hematology

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Hematology Oncology and Stem Cell Therapy is an international, peer-reviewed, open access journal that provides a vehicle for publications of high-quality clinical as well as basic science research reports in hematology and oncology. The contents of the journal also emphasize the growing importance of hematopoietic stem cell therapy for treatment of various benign and malignant hematologic disorders and certain solid tumors.The journal prioritizes publication of original research articles but also would give consideration for brief reports, review articles, special communications, and unique case reports. It also offers a special section for clinically relevant images that provide an important educational value.