The investigation of the frequency of the alpha-1-antitrypsin phenotype in patients with liver cirrhosis.

IF 1.1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Hormone Molecular Biology and Clinical Investigation Pub Date : 2022-12-01 DOI:10.1515/hmbci-2022-0001

Mehdi Afsharinasab, Amir Hossein Akbari, Vahid Mirzaei, Mehdi Mahmoodi, Mohammad Reza Hajizadeh, Jamal Amri, Alireza Khoshdel

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引用次数: 1

Abstract

Objectives: Alpha-1-antitrypsin (AAT) has different phenotypes. Evidence suggests that the abundance of each of these phenotypes may be associated with a disease. The purpose of this study was to evaluate the frequency of AAT phenotypes in patients with liver cirrhosis as well as in healthy individuals.

Methods: In this study, 42 patients with liver cirrhosis were selected. The results of the previous research done by the researcher on healthy individuals were used to construct the control group. After obtaining informed consent, 5 mL of fasting venous blood sample was taken, and phenotypes were analyzed by isoelectric focusing. Data were analyzed using Chi-square and Fisher's exact tests at a significant level of 0.05.

Results: The results of this study indicated that all 42 healthy subjects had an MM allele (100%). However, among 42 patients, 35 (83.3%) had an MM allele, 5 (11.9%) had an MS allele, and 2 (4.8%) had MZ allele. The difference between the two groups was significant (p=0.02). There was no difference between men and women in the allele type (p=0.557).

Conclusions: This study revealed that MS and MZ alleles were observed only in patients with liver cirrhosis, and none of these alleles were found in healthy subjects. Therefore, MS and MZ alleles can be further investigated as risk factors for liver cirrhosis.

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肝硬化患者α -1-抗胰蛋白酶表型频率的研究。

目的:α -1抗胰蛋白酶(AAT)具有不同的表型。有证据表明，这些表型的丰富程度可能与疾病有关。本研究的目的是评估肝硬化患者和健康人AAT表型的频率。方法:选取42例肝硬化患者作为研究对象。研究者之前对健康个体的研究结果被用来构建对照组。获得知情同意后，取空腹静脉血5 mL，等电聚焦分析表型。数据分析采用卡方检验和Fisher精确检验，显著水平为0.05。结果:42名健康受试者均存在MM等位基因(100%)。42例患者中，MM等位基因35例(83.3%)，MS等位基因5例(11.9%)，MZ等位基因2例(4.8%)。两组间差异有统计学意义(p=0.02)。男性和女性在等位基因类型上没有差异(p=0.557)。结论:本研究发现MS和MZ等位基因仅在肝硬化患者中存在，而在健康人群中未发现。因此，MS和MZ等位基因可作为肝硬化的危险因素进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

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期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.