Restless legs syndrome in patients with epilepsy: risk analysis, polysomnography, and quality of life evaluation.

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY Sleep Pub Date : 2024-06-13 DOI:10.1093/sleep/zsad054

Ying-Sheng Li, Wei-Chih Yeh, Ya-Hsien Chang, Chung-Yao Hsu

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Abstract

Study objectives: Restless legs syndrome (RLS) is a circadian rhythm related sensorimotor disorder due to brain iron deficiency, with lesion sites at the putamen and substantia nigra. However, epilepsy is a disease with abnormal electric discharge from the cortex and can be triggered with iron disequilibrium. We designed a case-control study to discover the association between epilepsy and RLS.

Methods: A total of 24 patients with epilepsy and RLS and 72 patients with epilepsy without RLS were included. Most of the patients underwent polysomnography and video electroencephalogram tests and took sleep questionnaires. We collected information on seizure characteristics, including general or focal onset, epileptogenic focus, current antiseizure medications, medically responsive epilepsy or refractory epilepsy, and nocturnal attacks. The sleep architectures of the two groups were compared. We analyzed the risk factors for RLS using multivariate logistic regression.

Results: Among the patients with epilepsy, the occurrence of RLS was associated with refractory epilepsy (OR 6.422, p = 0.002) and nocturnal seizures (OR 4.960, p = 0.005). Sleep parameters were not significantly associated with RLS status. Quality of life was significantly impaired in the group with RLS in both the physical and mental domains.

Conclusions: Refractory epilepsy and nocturnal seizures were strongly correlated with RLS in patients with epilepsy. RLS should be considered a predictable comorbidity in patients with epilepsy. The management of RLS not only led to better control of the patient's epilepsy but also improved their quality of life.

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癫痫患者的不安腿综合征：风险分析、多导睡眠图和生活质量评估。

研究目的：不宁腿综合征（RLS）是一种与昼夜节律相关的感觉运动失调症，是由于大脑缺铁引起的，病变部位位于普鲁士门和黑质。然而，癫痫是一种大脑皮层异常放电的疾病，铁失衡也可能诱发癫痫。我们设计了一项病例对照研究，以发现癫痫与 RLS 之间的关联：方法：共纳入 24 名癫痫合并 RLS 患者和 72 名癫痫但无 RLS 的患者。大部分患者接受了多导睡眠图和视频脑电图测试，并进行了睡眠问卷调查。我们收集了有关癫痫发作特征的信息，包括全身性或局灶性发作、致痫灶、目前服用的抗癫痫药物、药物反应性癫痫或难治性癫痫以及夜间发作。我们对两组患者的睡眠结构进行了比较。我们使用多变量逻辑回归分析了RLS的风险因素：结果：在癫痫患者中，RLS的发生与难治性癫痫（OR 6.422，P = 0.002）和夜间发作（OR 4.960，P = 0.005）相关。睡眠参数与 RLS 状态无明显关联。RLS患者的生活质量在身体和精神方面都明显下降：结论：难治性癫痫和夜间癫痫发作与癫痫患者的 RLS 密切相关。应将 RLS 视为癫痫患者的一种可预测的并发症。对 RLS 的治疗不仅能更好地控制患者的癫痫，还能改善他们的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep 医学-临床神经学

CiteScore

10.10

自引率

10.70%

发文量

1134

审稿时长

3 months

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.