Antibiotic Susceptibility Patterns for Carbapenem-Resistant Enterobacteriaceae.

IF 2.8 Q3 MICROBIOLOGY International Journal of Microbiology Pub Date : 2023-01-01 DOI:10.1155/2023/8920977

Shahnaz Armin, Fatemeh Fallah, Abdollah Karimi, Fereshteh Karbasiyan, Masoud Alebouyeh, Sedigheh Rafiei Tabatabaei, Maryam Rajabnejad, Roxana Mansour Ghanaie, Seyed Alireza Fahimzad, Nafiseh Abdollahi, Hannan Khodaei, Leila Azimi

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引用次数: 3

Abstract

Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant Enterobacteriaceae (CRE) to new and old antibiotics. In this study, Klebsiella pneumoniae, E. coli, and Enterobacter spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 E. coli, 696 K. pneumoniae, and 621 Enterobacter spp. were collected from 10 hospitals in Iran in one year. Fifty-four E. coli (4.4%), 84 K. pneumoniae (12%), and 51 Enterobacter spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for Enterobacter spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.

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耐碳青霉烯肠杆菌科细菌的药敏模式。

碳青霉烯是一种广谱β -内酰胺类抗生素，被认为是治疗耐药革兰氏阴性菌的最后选择。因此，肠杆菌科碳青霉烯类耐药率的上升是一个紧迫的公共卫生威胁。本研究旨在评价碳青霉烯耐药肠杆菌科(CRE)对新旧抗生素的药敏模式。本研究收集了伊朗10家医院一年的肺炎克雷伯菌、大肠杆菌和肠杆菌。对收集的细菌进行鉴定后，通过对美罗培南和/或亚胺培南片的耐药性来识别CRE。采用纸片扩散法检测CRE对磷霉素、利福平、甲硝唑、替加环素、氨曲南的药敏，MIC法检测粘菌素的药敏。本研究在一年内从伊朗10家医院收集了1222株大肠杆菌、696株肺炎克雷伯菌和621株肠杆菌。大肠杆菌54例(4.4%)，肺炎克雷伯菌84例(12%)，肠杆菌51例(8.2%)。所有CRE菌株均对甲硝唑和利福平耐药。替加环素对肠杆菌CRE和左氧氟沙星的敏感性最高，替加环素对CRE的敏感性可接受。因此，我们建议临床医生考虑使用这种有价值的抗生素来治疗CRE。

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来源期刊

International Journal of Microbiology MICROBIOLOGY-

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Microbiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on microorganisms and their interaction with hosts and the environment. The journal covers all microbes, including bacteria, fungi, viruses, archaea, and protozoa. Basic science will be considered, as well as medical and applied research.