Effects of Modified Baizhu Shaoyao San on Postoperative Diarrhea in Colorectal Cancer Patients: A Single-Blind, Randomized Controlled Trial.

IF 1.1 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Complementary Medicine Research Pub Date : 2023-01-01 DOI:10.1159/000527706

Menghui Fei, Jiwen Zhang, Cuicui Zhu, Ming Luo, Lina Zhang, Yongmei Wu

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Abstract

Introduction: Postoperative gastrointestinal tract dysfunction is considered a common complication affecting patients undergoing intestinal surgery. This research aims to provide evidence to assess the efficacy and safety of Baizhu Shaoyao San (BSS) or modified BSS in treating postoperative diarrhea of colorectal cancer patients.

Methods: Eighty patients with colorectal cancer were randomized within 2 weeks after surgery to receive either modified BSS or Loperamide combined with the respective dummy. The curative effect was evaluated with the traditional Chinese medicine (TCM) syndrome score. Determination of motilin and gastrin in plasma was conducted utilizing ELISA.

Results: Compared with Loperamide therapy, the efficacy of modified BSS was statistically significant, the TCM syndrome score decreased, and the total effective rate increased. Levels of motilin and gastrin in plasma decreased.

Conclusion: The curative effect and safety of modified BSS were statistically significant.

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白术少药散加减对结直肠癌术后腹泻的影响:单盲、随机对照试验。

前言:术后胃肠道功能障碍被认为是影响肠道手术患者的常见并发症。本研究旨在评价白术少药散(BSS)或改良BSS治疗结直肠癌术后腹泻的疗效和安全性。方法:80例结直肠癌患者在术后2周内随机接受改良BSS或洛哌丁胺联合各自的假体治疗。采用中医证候评分法评价疗效。采用ELISA法测定血浆胃动素和胃泌素。结果:与洛哌丁胺治疗相比，改良BSS的疗效有统计学意义，中医证候评分降低，总有效率提高。血浆中胃动素和胃泌素水平降低。结论:改良BSS的疗效及安全性均有统计学意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Complementary Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

2.90

自引率

5.60%

发文量

期刊介绍： Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR