Mohammad Mahdi Parvizi, Sara Foolad, Ali Zeighami, Mohammad Reza Namazi, Mojtaba Heydari
Introduction: Hyperthyroidism is a common endocrinology condition that could affect several aspects of the patient's life.
Case presentation: We present a 27-year-old woman who was sent to the traditional Persian medicine (TPM) clinic with a diagnosis of uncontrolled chronic hyperthyroidism (lower levels of thyroid stimulating hormone (TSH) and higher levels of T3 and T4) and its complications, such as developing exophthalmos, palpitations, anxiety, sleep problems, hair loss, and dry skin. The patient was under treatment with prednisolone and methimazole for up to one year, but no acceptable improvement was achieved. The patient received a package of TPM recommendations, which included lifestyle modification, Melissa officinalis herbal tea, and Persian barley water. The patient was followed for one year. After two months of follow-up of the patient, the level of TSH increased, and the level of T3 and T4 decreased. In addition, the patient's symptoms, including exophthalmos, palpitation, anxiety, sleep disturbance, and dryness of the skin, were improved considerably. After three months of consumption of the TPM-based regime and prescription, the serum levels of TSH, T3, and T4, of the patient were in normal ranges. In a one-year follow-up of the patient, the patient's condition was stable and her thyroid function tests were normal. We hereby present the following case to be in line with the CAse REports (CARE) checklist.
Conclusion: It appears that TPM lifestyle recommendations, Melissa officinalis herbal tea, and Persian barley water were effective in treating the patient with uncontrolled hyperthyroidism. We recommend further studies and clinical trial designs in this regard.
{"title":"Successful maintenance treatment of a patient with resistant hyperthyroidism with traditional Persian medicine recommendations: A case report and literature review.","authors":"Mohammad Mahdi Parvizi, Sara Foolad, Ali Zeighami, Mohammad Reza Namazi, Mojtaba Heydari","doi":"10.1159/000541255","DOIUrl":"https://doi.org/10.1159/000541255","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperthyroidism is a common endocrinology condition that could affect several aspects of the patient's life.</p><p><strong>Case presentation: </strong>We present a 27-year-old woman who was sent to the traditional Persian medicine (TPM) clinic with a diagnosis of uncontrolled chronic hyperthyroidism (lower levels of thyroid stimulating hormone (TSH) and higher levels of T3 and T4) and its complications, such as developing exophthalmos, palpitations, anxiety, sleep problems, hair loss, and dry skin. The patient was under treatment with prednisolone and methimazole for up to one year, but no acceptable improvement was achieved. The patient received a package of TPM recommendations, which included lifestyle modification, Melissa officinalis herbal tea, and Persian barley water. The patient was followed for one year. After two months of follow-up of the patient, the level of TSH increased, and the level of T3 and T4 decreased. In addition, the patient's symptoms, including exophthalmos, palpitation, anxiety, sleep disturbance, and dryness of the skin, were improved considerably. After three months of consumption of the TPM-based regime and prescription, the serum levels of TSH, T3, and T4, of the patient were in normal ranges. In a one-year follow-up of the patient, the patient's condition was stable and her thyroid function tests were normal. We hereby present the following case to be in line with the CAse REports (CARE) checklist.</p><p><strong>Conclusion: </strong>It appears that TPM lifestyle recommendations, Melissa officinalis herbal tea, and Persian barley water were effective in treating the patient with uncontrolled hyperthyroidism. We recommend further studies and clinical trial designs in this regard.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The effects of work-related stress (WRS) on occupational health often lead to reduced well-being and long-term sick leave. Itching or pruritus, a skin inflammation with a rash that provokes the desire to scratch, often occurs during stressful periods in clients with a history of atopic dermatitis (AD).
Case presentation: This client suffered from severe WRS together with long-term therapeutically resistant pruritus for eight years, resulting in severe itching. He was provided with an intervention with acupuncture treatment (AT) to prevent a long-term sick leave. The results showed an unexpected reduction in itching, skin inflammation, and eczema. Additionally, the treatment enhanced the client´s emotional and cognitive well-being and eliminated the need for sick leave.
Conclusion: Acupuncture can be an effective complementary treatment for severe itching related to WRS, in addition to standard medical treatments.
{"title":"Severe itch related to hard workload treated with acupuncture. Unexpected results. Case report.","authors":"Lisbeth Dahlin, Anja Finn","doi":"10.1159/000541191","DOIUrl":"https://doi.org/10.1159/000541191","url":null,"abstract":"<p><strong>Introduction: </strong>The effects of work-related stress (WRS) on occupational health often lead to reduced well-being and long-term sick leave. Itching or pruritus, a skin inflammation with a rash that provokes the desire to scratch, often occurs during stressful periods in clients with a history of atopic dermatitis (AD).</p><p><strong>Case presentation: </strong>This client suffered from severe WRS together with long-term therapeutically resistant pruritus for eight years, resulting in severe itching. He was provided with an intervention with acupuncture treatment (AT) to prevent a long-term sick leave. The results showed an unexpected reduction in itching, skin inflammation, and eczema. Additionally, the treatment enhanced the client´s emotional and cognitive well-being and eliminated the need for sick leave.</p><p><strong>Conclusion: </strong>Acupuncture can be an effective complementary treatment for severe itching related to WRS, in addition to standard medical treatments.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aliye Dogan-Gangal, Belgin Akin, Deniz Kocoglu-Tanyer
Introduction: Music is a non-pharmacological intervention often used to improve maternal mental health during pregnancy. However, there is limited evidence regarding the effectiveness of music-based interventions on maternal and fetal parameters during pregnancy. We present a systematic review of the available research literature on the effects of music interventions on maternal and fetal parameters.
Methods: A comprehensive literature search was conducted on the Web of Science, PubMed, Science Direct, Scopus, CINAHL, Medline, Cochrane, ProQuest, and Turkish databases. The review included randomized controlled and quasi-experimental studies. Two independent authors evaluated the methodological quality of each study using the Quality Assessment Tool for Quantitative Studies. The study was registered in PROSPERO (CRD42018102914).
Results: The literature review yielded a total of 723 studies. Among these studies, 13 were included in this study. Most of the studies involving low-risk pregnant women reported that music had no effect on stress but reduced anxiety and depression. The effect of music on pregnant women's blood pressure varied depending on the presence of medical conditions that could affect their blood pressure. While some studies showed that music interventions effectively increased fetal movement and acceleration, the available findings were limited.
Conclusion: Healthcare professionals can use simple, cost-effective, and practical music interventions to improve maternal mental health during pregnancy without neglecting medical treatment. Future well-designed studies are recommended to investigate the effects of music on maternal psychological, physiological parameters and fetal parameters in high-risk pregnancies.
简介音乐是一种非药物干预措施,常用来改善孕期孕产妇的心理健康。然而,关于音乐干预对孕期孕产妇和胎儿参数的有效性的证据却很有限。我们对现有关于音乐干预对母体和胎儿参数影响的研究文献进行了系统性回顾:我们在 Web of Science、PubMed、Science Direct、Scopus、CINAHL、Medline、Cochrane、ProQuest 和 Turkish 数据库中进行了全面的文献检索。综述包括随机对照研究和准实验研究。两位独立作者使用定量研究质量评估工具对每项研究的方法学质量进行了评估。该研究已在 PROSPERO(CRD42018102914)上注册:结果:文献综述共收集到 723 项研究。结果:文献综述共收集到 723 项研究,其中 13 项被纳入本研究。大多数涉及低风险孕妇的研究报告称,音乐对压力没有影响,但能减轻焦虑和抑郁。音乐对孕妇血压的影响因孕妇是否患有可能影响血压的疾病而异。虽然一些研究表明音乐干预能有效增加胎动和加速,但现有研究结果有限:结论:医护人员可以使用简单、经济、实用的音乐干预措施来改善孕期孕产妇的心理健康,同时又不会忽视医疗。建议今后开展精心设计的研究,探讨音乐对高危妊娠中孕产妇心理、生理参数和胎儿参数的影响。
{"title":"Effect of Music-Based Interventions on Maternal and Fetal Parameters During Pregnancy: A Systematic Review.","authors":"Aliye Dogan-Gangal, Belgin Akin, Deniz Kocoglu-Tanyer","doi":"10.1159/000540263","DOIUrl":"https://doi.org/10.1159/000540263","url":null,"abstract":"<p><strong>Introduction: </strong>Music is a non-pharmacological intervention often used to improve maternal mental health during pregnancy. However, there is limited evidence regarding the effectiveness of music-based interventions on maternal and fetal parameters during pregnancy. We present a systematic review of the available research literature on the effects of music interventions on maternal and fetal parameters.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted on the Web of Science, PubMed, Science Direct, Scopus, CINAHL, Medline, Cochrane, ProQuest, and Turkish databases. The review included randomized controlled and quasi-experimental studies. Two independent authors evaluated the methodological quality of each study using the Quality Assessment Tool for Quantitative Studies. The study was registered in PROSPERO (CRD42018102914).</p><p><strong>Results: </strong>The literature review yielded a total of 723 studies. Among these studies, 13 were included in this study. Most of the studies involving low-risk pregnant women reported that music had no effect on stress but reduced anxiety and depression. The effect of music on pregnant women's blood pressure varied depending on the presence of medical conditions that could affect their blood pressure. While some studies showed that music interventions effectively increased fetal movement and acceleration, the available findings were limited.</p><p><strong>Conclusion: </strong>Healthcare professionals can use simple, cost-effective, and practical music interventions to improve maternal mental health during pregnancy without neglecting medical treatment. Future well-designed studies are recommended to investigate the effects of music on maternal psychological, physiological parameters and fetal parameters in high-risk pregnancies.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mikael Källman, Stefan Bergström, Georg Holgersson, Jacob Järås, Ruth Randén Engqvist, Michael Bergqvist
Background: Complementary and alternative medicine (CAM) is widely used by patients with cancer. There is research that indicates that the use of CAM is more prevalent in rural areas compared to urban areas. Regarding the scope and specifics of patient's use of CAM in Sweden, particularly in rural areas, there is a dearth of information. The aim of this study was to estimate the extent and characteristics of CAM use among cancer patients in the rural areas of Region Gävleborg.
Methods: A total of 631 questionnaires were sent out, and 376 of those were returned, translating to a 59.6% response rate. Oncology patients received questionnaires on their initial appointment for curative care at Gävle Hospital's Oncology Department. When enrolling in palliative outpatient care in their homes, as well as on their initial visit, palliative patients were sought out. Standard descriptive statistics were used to present the characteristics of the respondents. To determine odds ratios (ORs) and potential factors (age, gender, diagnosis, and education) of CAM use after cancer diagnosis, a multivariable logistic model was constructed.
Results: Based on clinical observations, the authors' hypothesis-that complementary and alternative medicine (CAM) use is particularly common in smaller towns in the Hälsingland region-was verified in this study. Moreover, the majority of those that stand out are younger and reside in Hälsingland's small towns. It seems that this applies to both men and women.
Conclusions: CAM seems to be utilised more frequently by patients residing in rural areas. It is crucial that carers enquire about all of the patient's health-seeking activities. It is necessary to conduct further research on the usage of complementary and alternative medicine (CAM) in rural areas and the potential cultural influences on this use. From a sociological standpoint, it's critical to draw attention to the fact that CAM use can be more prevalent in some rural areas, particularly in centralised societies where access to healthcare is more difficult.
{"title":"Regional perspectives on Complementary and Alternative Medicine: Results of a regional survey.","authors":"Mikael Källman, Stefan Bergström, Georg Holgersson, Jacob Järås, Ruth Randén Engqvist, Michael Bergqvist","doi":"10.1159/000540663","DOIUrl":"https://doi.org/10.1159/000540663","url":null,"abstract":"<p><strong>Background: </strong>Complementary and alternative medicine (CAM) is widely used by patients with cancer. There is research that indicates that the use of CAM is more prevalent in rural areas compared to urban areas. Regarding the scope and specifics of patient's use of CAM in Sweden, particularly in rural areas, there is a dearth of information. The aim of this study was to estimate the extent and characteristics of CAM use among cancer patients in the rural areas of Region Gävleborg.</p><p><strong>Methods: </strong>A total of 631 questionnaires were sent out, and 376 of those were returned, translating to a 59.6% response rate. Oncology patients received questionnaires on their initial appointment for curative care at Gävle Hospital's Oncology Department. When enrolling in palliative outpatient care in their homes, as well as on their initial visit, palliative patients were sought out. Standard descriptive statistics were used to present the characteristics of the respondents. To determine odds ratios (ORs) and potential factors (age, gender, diagnosis, and education) of CAM use after cancer diagnosis, a multivariable logistic model was constructed.</p><p><strong>Results: </strong>Based on clinical observations, the authors' hypothesis-that complementary and alternative medicine (CAM) use is particularly common in smaller towns in the Hälsingland region-was verified in this study. Moreover, the majority of those that stand out are younger and reside in Hälsingland's small towns. It seems that this applies to both men and women.</p><p><strong>Conclusions: </strong>CAM seems to be utilised more frequently by patients residing in rural areas. It is crucial that carers enquire about all of the patient's health-seeking activities. It is necessary to conduct further research on the usage of complementary and alternative medicine (CAM) in rural areas and the potential cultural influences on this use. From a sociological standpoint, it's critical to draw attention to the fact that CAM use can be more prevalent in some rural areas, particularly in centralised societies where access to healthcare is more difficult.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Infectious diarrhea (ID) is a highly prevalent disease worldwide that poses a substantial risk to human well-being. In China, numerous clinical studies have investigated the efficacy of Gegen Qinlian decoction (GGQLD) in treating ID. However, there is a need for additional rigorous and evidence-based medical research to enhance physicians' confidence in their prescribing practices.
Methods: Seven Chinese and English databases were systematically searched. The Cochrane Risk of Bias tool was used to assess the quality of the included studies. Meta-analysis was conducted using RevMan 5.3, and Stata 16.0 was used for the sensitivity analysis. Trial sequential analysis was performed using TSA v0.9, and GRADEprofiler was utilized to evaluate the quality of evidence.
Results: A total of 12 randomized controlled trials (RCTs) involving 1,240 patients were included. The meta-analysis demonstrated that the combination of GGQLD with conventional Western medicine had better effects on clinical efficacy (relative risk [RR] = 1.15, 95% confidence interval [CI] [1.10, 1.20]), duration of diarrhea symptoms (weighted mean difference [WMD] = -10.96, 95% CI [-11.97, -9.96]), duration of abdominal pain symptoms (WMD = -12.01, 95% CI [-14.12, -9.90]), duration of fever symptoms (WMD = -11.91, 95% CI [-13.39, -10.43]), interleukin-6 levels (WMD = -113.59, 95% CI [-113.03, -108.14]), and tumor necrosis factor-α levels (WMD = -62.18, 95% CI [-65.25, -59.11]) and that no significant adverse reactions occurred (RR = 0.45, 95% CI [0.10, 1.97]). The sample size of the included studies reached the expected size. The quality of evidence for outcome indicators was rated as low or very low.
Conclusions: The combination of GGQLD with conventional Western medicine demonstrates promising efficacy and safety in treating ID. Nonetheless, more high-quality RCTs are required to confirm this conclusion.
背景:感染性腹泻(ID)是一种全球高发疾病,对人类健康构成了巨大威胁。在中国,许多临床研究都探讨了格根秦连煎(GGQLD)治疗感染性腹泻的疗效。然而,还需要更多严格的循证医学研究,以增强医生的处方信心:方法:系统检索了七个中英文数据库。方法:系统检索了 7 个中英文数据库,并使用 Cochrane Risk of Bias 工具评估纳入研究的质量。使用 RevMan 5.3 进行 Meta 分析,使用 Stata 16.0 进行敏感性分析。使用TSA v0.9进行试验序列分析,并使用GRADEprofiler评估证据质量:共纳入了 12 项随机对照试验(RCT),涉及 1240 名患者。荟萃分析表明,GGQLD与常规西药联合治疗在临床疗效(RR=1.15,95% CI [1.10,1.20])、腹泻症状持续时间(WMD=-10.96,95% CI [-11.97,-9.96])、腹痛症状持续时间(WMD=-12.01,95% CI [-14.12,-9.90])、发热症状持续时间(WMD=-11.91,95% CI [-13.39,-10.43])、白细胞介素-6(IL-6)水平(WMD=-113.59,95% CI [-113.03,-108.14])和肿瘤坏死因子-α(TNF-α)水平(WMD=-62.18,95% CI[-65.25,-59.11]),且未出现明显的不良反应(RR = 0.45,95% CI [0.10,1.97])。纳入研究的样本量达到了预期规模。结果指标的证据质量被评为低或很低:结论:GGQLD与传统西药联合治疗ID具有良好的疗效和安全性。尽管如此,还需要更多高质量的 RCT 研究来证实这一结论。
{"title":"Gegen Qinlian Decoction Combined with Conventional Western Medicine for the Treatment of Infectious Diarrhea: A Systematic Review and Trial Sequential Analysis.","authors":"Fei Wang, Qianyan Wu, Qingyuan Zhang, Shuaishuai Ma, Kangyi Wang, Hui Jian, Ying Zhang","doi":"10.1159/000540793","DOIUrl":"10.1159/000540793","url":null,"abstract":"<p><strong>Introduction: </strong>Infectious diarrhea (ID) is a highly prevalent disease worldwide that poses a substantial risk to human well-being. In China, numerous clinical studies have investigated the efficacy of Gegen Qinlian decoction (GGQLD) in treating ID. However, there is a need for additional rigorous and evidence-based medical research to enhance physicians' confidence in their prescribing practices.</p><p><strong>Methods: </strong>Seven Chinese and English databases were systematically searched. The Cochrane Risk of Bias tool was used to assess the quality of the included studies. Meta-analysis was conducted using RevMan 5.3, and Stata 16.0 was used for the sensitivity analysis. Trial sequential analysis was performed using TSA v0.9, and GRADEprofiler was utilized to evaluate the quality of evidence.</p><p><strong>Results: </strong>A total of 12 randomized controlled trials (RCTs) involving 1,240 patients were included. The meta-analysis demonstrated that the combination of GGQLD with conventional Western medicine had better effects on clinical efficacy (relative risk [RR] = 1.15, 95% confidence interval [CI] [1.10, 1.20]), duration of diarrhea symptoms (weighted mean difference [WMD] = -10.96, 95% CI [-11.97, -9.96]), duration of abdominal pain symptoms (WMD = -12.01, 95% CI [-14.12, -9.90]), duration of fever symptoms (WMD = -11.91, 95% CI [-13.39, -10.43]), interleukin-6 levels (WMD = -113.59, 95% CI [-113.03, -108.14]), and tumor necrosis factor-α levels (WMD = -62.18, 95% CI [-65.25, -59.11]) and that no significant adverse reactions occurred (RR = 0.45, 95% CI [0.10, 1.97]). The sample size of the included studies reached the expected size. The quality of evidence for outcome indicators was rated as low or very low.</p><p><strong>Conclusions: </strong>The combination of GGQLD with conventional Western medicine demonstrates promising efficacy and safety in treating ID. Nonetheless, more high-quality RCTs are required to confirm this conclusion.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xijing Yu, Mengyu Jin, Hui Huang, Fenfen Qiu, Lele Geng, Rong Guo, Xiaoyan Zhu, Xiuwu Hu
Objective: To study the effect of long snake moxibustion intervention on gut microbiota of patients with ankylosing spondylitis (AS) by 16S rDNA sequencing technology.
Methods: 30 AS patients and 30 healthy volunteers were recruited and treated with long snake moxibustion once a week for 12 weeks. AS patients were divided into pre-treatment and post-treatment groups. VAS, BASDAI and BASFI scores of AS patients before and after treatment were collected. 16S rDNA high-throughput sequencing technology was used to analyze the characteristics and differences of gut microbiota in AS patients before and after treatment and in healthy volunteers.
Results: VAS, BASDAI and BASFI scores of AS patients after long snake moxibustion treatment were lower than those of pre-treatment group (P<0.05). The results of gut microbiota Alpha diversity showed that ace and chao1 index of the post-treatment group were higher than those of the healthy group (P<0.05), but there was no statistical significance in ace and chao1 index between the pre-treatment group and the post-treatment group (P>0.05). Beta diversity analysis showed that mild classification aggregation occurred between the healthy group and the pre-treatment group , but did not reach a significant level, and there was no significant difference between the the pre-treatment group and the post-treatment group. The results of species abundance showed that, at the phylum level, compared with the healthy group, the relative abundance of Firmicutes and Proteobacteria decreased in the pre-treatment group, while the relative abundance of Bacteroidetes and Actinobacteria increased. Compared with the pre-treatment group, the relative abundance of Firmicutes increased and the relative abundance of Actinobacteria decreased in the post-treatment group, but there were no statistically significant differences in the above changes (P>0.05). At the genus level, compared with the healthy group, the relative abundances of Subdoligranulum in the pre-treatment group were increased (P<0.05), while the relative abundances of Bifidobacterium and Streptococcus were decreased (P<0.05). Compared with the pre-treatment group, the relative abundance of Romboutsia in the post-treatment group was increased (P<0.05).
Conclusion: Long snake moxibustion can obviously improve the clinical symptoms of AS patients. The possible mechanism of action is related to regulating the abundance of gut microbiota, increasing beneficial bacteria and restoring the homeostasis of gut microorganisms.
目的方法:招募30名强直性脊柱炎(AS)患者和30名健康志愿者,对其进行长蛇灸治疗,每周一次,连续12周。将 AS 患者分为治疗前和治疗后两组。收集治疗前后 AS 患者的 VAS、BASDAI 和 BASFI 评分。采用16S rDNA高通量测序技术分析了治疗前后强直性脊柱炎患者和健康志愿者肠道微生物群的特征和差异:结果:长蛇灸治疗后强直性脊柱炎患者的VAS、BASDAI和BASFI评分均低于治疗前(P<0.05)。肠道微生物群Alpha多样性结果显示,治疗后组的ace和chao1指数高于健康组(P<0.05),但治疗前组与治疗后组的ace和chao1指数差异无统计学意义(P>0.05)。Beta 多样性分析表明,健康组与处理前组之间存在轻度分类聚集,但未达到显著水平,处理前组与处理后组之间无显著差异。物种丰度结果表明,与健康组相比,在门的层次上,处理前组的固着菌和变形菌相对丰度下降,而类杆菌和放线菌相对丰度上升。与治疗前相比,治疗后组的固缩菌相对丰度增加,放线菌相对丰度减少,但上述变化差异无统计学意义(P>0.05)。在菌属水平上,与健康组相比,治疗前组 Subdoligranulum 的相对丰度升高(P<0.05),而双歧杆菌和链球菌的相对丰度降低(P<0.05)。与治疗前相比,治疗后组的隆突菌相对丰度增加(P<0.05):结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状。结论:长蛇灸能明显改善强直性脊柱炎患者的临床症状,其作用机制可能与调节肠道微生物群的丰度、增加有益菌、恢复肠道微生物的平衡有关。
{"title":"Effect of long snake moxibustion on gut microbiota of patients with ankylosing spondylitis.","authors":"Xijing Yu, Mengyu Jin, Hui Huang, Fenfen Qiu, Lele Geng, Rong Guo, Xiaoyan Zhu, Xiuwu Hu","doi":"10.1159/000540271","DOIUrl":"https://doi.org/10.1159/000540271","url":null,"abstract":"<p><strong>Objective: </strong>To study the effect of long snake moxibustion intervention on gut microbiota of patients with ankylosing spondylitis (AS) by 16S rDNA sequencing technology.</p><p><strong>Methods: </strong>30 AS patients and 30 healthy volunteers were recruited and treated with long snake moxibustion once a week for 12 weeks. AS patients were divided into pre-treatment and post-treatment groups. VAS, BASDAI and BASFI scores of AS patients before and after treatment were collected. 16S rDNA high-throughput sequencing technology was used to analyze the characteristics and differences of gut microbiota in AS patients before and after treatment and in healthy volunteers.</p><p><strong>Results: </strong>VAS, BASDAI and BASFI scores of AS patients after long snake moxibustion treatment were lower than those of pre-treatment group (P<0.05). The results of gut microbiota Alpha diversity showed that ace and chao1 index of the post-treatment group were higher than those of the healthy group (P<0.05), but there was no statistical significance in ace and chao1 index between the pre-treatment group and the post-treatment group (P>0.05). Beta diversity analysis showed that mild classification aggregation occurred between the healthy group and the pre-treatment group , but did not reach a significant level, and there was no significant difference between the the pre-treatment group and the post-treatment group. The results of species abundance showed that, at the phylum level, compared with the healthy group, the relative abundance of Firmicutes and Proteobacteria decreased in the pre-treatment group, while the relative abundance of Bacteroidetes and Actinobacteria increased. Compared with the pre-treatment group, the relative abundance of Firmicutes increased and the relative abundance of Actinobacteria decreased in the post-treatment group, but there were no statistically significant differences in the above changes (P>0.05). At the genus level, compared with the healthy group, the relative abundances of Subdoligranulum in the pre-treatment group were increased (P<0.05), while the relative abundances of Bifidobacterium and Streptococcus were decreased (P<0.05). Compared with the pre-treatment group, the relative abundance of Romboutsia in the post-treatment group was increased (P<0.05).</p><p><strong>Conclusion: </strong>Long snake moxibustion can obviously improve the clinical symptoms of AS patients. The possible mechanism of action is related to regulating the abundance of gut microbiota, increasing beneficial bacteria and restoring the homeostasis of gut microorganisms.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carolin Breinlinger, Sara Meiß, Etienne Hanslian, Stefan Jordan, Michael Boschmann, Anika Rajput Khokhar, Andreas Michalsen, Daniela A Koppold
Background: A fasting conference and scientific symposium on fasting were held in Berlin in June 2023. Researchers and clinicians from around the world shared new findings, clinical insights, and work in progress during a 3-day program.
Summary: Different fasting regimens, including prolonged, short-term, intermittent fasting, and time-restricted eating were discussed for preventive and therapeutic settings. Experimental and clinical findings shared ranged from biochemical and cellular fasting responses to fasting-mimicking agents, the role of the gut microbiome, and immunological effects. Clinically, a special focus was placed upon metabolic, autoimmune, neurodegenerative, and oncological diseases. The discussion also covered how modern technologies, practical adaptations to traditional protocols, and a supportive network of specialized physicians can assist in the practical application of fasting, among other subjects.
Key messages: Dose-response relationships, gender aspects, and the subjective experience of fasting seem promising for future research, while further investigation of religious fasting may offer deeper insights into motivational and health aspects.
{"title":"Fasting in Science and Clinics: A Report on Proceedings from the International Scientific Symposium and Conference on Fasting in Berlin (June 2023).","authors":"Carolin Breinlinger, Sara Meiß, Etienne Hanslian, Stefan Jordan, Michael Boschmann, Anika Rajput Khokhar, Andreas Michalsen, Daniela A Koppold","doi":"10.1159/000540668","DOIUrl":"10.1159/000540668","url":null,"abstract":"<p><strong>Background: </strong>A fasting conference and scientific symposium on fasting were held in Berlin in June 2023. Researchers and clinicians from around the world shared new findings, clinical insights, and work in progress during a 3-day program.</p><p><strong>Summary: </strong>Different fasting regimens, including prolonged, short-term, intermittent fasting, and time-restricted eating were discussed for preventive and therapeutic settings. Experimental and clinical findings shared ranged from biochemical and cellular fasting responses to fasting-mimicking agents, the role of the gut microbiome, and immunological effects. Clinically, a special focus was placed upon metabolic, autoimmune, neurodegenerative, and oncological diseases. The discussion also covered how modern technologies, practical adaptations to traditional protocols, and a supportive network of specialized physicians can assist in the practical application of fasting, among other subjects.</p><p><strong>Key messages: </strong>Dose-response relationships, gender aspects, and the subjective experience of fasting seem promising for future research, while further investigation of religious fasting may offer deeper insights into motivational and health aspects.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Moxibustion is clinically used for treating various chronic diseases; however, the reporting quality of current published RCTs of moxibustion is unclear. The objective of this study was to assess the reporting quality of RCTs focusing on moxibustion as a treatment for chronic diseases.
Methods: Seven databases were searched to identify relevant RCTs. Criteria for evaluating the reporting quality of standard RCT elements and moxibustion intervention-related information were developed based on the CONSORT statement and its STRICTOM extension, respectively. Multivariate regression models were used to investigate factors impacting reporting quality.
Results: A total of 310 RCTs were included, with 41 (7.6%) published in English journals and 269 (92.4%) in Chinese journals. The median CONSORT and STRICTOM scores of these RCTs, with a maximum score of 100, were 41.2 and 62.9, respectively. RCTs with a later publication year and protocol registration or ethical approval exhibited significantly higher CONSORT and STRICTOM scores. Higher CONSORT scores were also significantly associated with English language publication, funding support, and inclusion of a safety evaluation, while higher STRICTOM scores were additionally associated with an active control design.
Conclusion: The reporting quality of RCTs focusing on moxibustion treatment for chronic diseases is subpar, with gradual but limited improvement over the last 25 years. To enhance the reporting quality of moxibustion RCTs, researchers should develop a comprehensive study protocol and standardize result reporting based on CONSORT and STRICTOM statements. Registration platforms, ethical approval organizations, funders, and journals can also contribute to this improvement by bolstering structured information reporting in the review process.
{"title":"Assessment of Quality of Reporting in Randomized Controlled Trials of Moxibustion for Chronic Diseases Using the Consolidated Standards of Reporting Trials and Standards for Reporting Interventions in Clinical Trials of Moxibustion Statements.","authors":"Jianrong Chen, Guihua Deng, Huilin Liu, Qiuyun Xue, Yaojun Cai, Jiao Wang, Sheng Xu, Xu Zhou, Jiancheng Wang","doi":"10.1159/000540641","DOIUrl":"10.1159/000540641","url":null,"abstract":"<p><strong>Introduction: </strong>Moxibustion is clinically used for treating various chronic diseases; however, the reporting quality of current published RCTs of moxibustion is unclear. The objective of this study was to assess the reporting quality of RCTs focusing on moxibustion as a treatment for chronic diseases.</p><p><strong>Methods: </strong>Seven databases were searched to identify relevant RCTs. Criteria for evaluating the reporting quality of standard RCT elements and moxibustion intervention-related information were developed based on the CONSORT statement and its STRICTOM extension, respectively. Multivariate regression models were used to investigate factors impacting reporting quality.</p><p><strong>Results: </strong>A total of 310 RCTs were included, with 41 (7.6%) published in English journals and 269 (92.4%) in Chinese journals. The median CONSORT and STRICTOM scores of these RCTs, with a maximum score of 100, were 41.2 and 62.9, respectively. RCTs with a later publication year and protocol registration or ethical approval exhibited significantly higher CONSORT and STRICTOM scores. Higher CONSORT scores were also significantly associated with English language publication, funding support, and inclusion of a safety evaluation, while higher STRICTOM scores were additionally associated with an active control design.</p><p><strong>Conclusion: </strong>The reporting quality of RCTs focusing on moxibustion treatment for chronic diseases is subpar, with gradual but limited improvement over the last 25 years. To enhance the reporting quality of moxibustion RCTs, researchers should develop a comprehensive study protocol and standardize result reporting based on CONSORT and STRICTOM statements. Registration platforms, ethical approval organizations, funders, and journals can also contribute to this improvement by bolstering structured information reporting in the review process.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harald Matthes, Erik W Baars, Benno Brinkhaus, Moritz Christoph, Friedrich Edelhäuser, Christian Grah, Carsten Gründemann, Christian Keßler, David Martin, Andreas Michalsen, Bernd Rosslenbroich, Jana Siroka, Georg Soldner, Michael Teut, Jan Vagedes, Stefan N Willich
Background: Considering the analogies between the disruption in ecological systems and in individuals, the concept of integrative medicine is extended to the One Health concept and integrative medicine is introduced as an innovative model for guidance/correction in patients' therapy as well as in ecological realignment.
Summary: The specific elements of integrative medicine that can be applied to human health as well as to environmental health are described (e.g. self-regulation, salutogenic healing processes, transdisciplinary multimodal approaches, methodological pluralism). The need for sustainable use of limited resources in medicine and pharmacy is pointed out. As examples for urgent action, the need of taking into account the whole life cycle of pharmaceutical products as well as the impact of diet for human and planetary health are mentioned.
Key message: Self-regulation plays a crucial role in human and environmental health; sustainable promotion of self-regulation enables people to become co-creators of their own health. Such a fundamental change requires transformation of one's inner relationship to nature and to oneself. The aim of the mini-review was to concretize individual fields of action and to investigate the question of whether the concepts of integrative medicine can be transferred from humans to the environment and thus to planetary health and whether this makes sense.
{"title":"The Earth as a Living Organism: Contribution of Integrative Medicine to the Healing of Our Planet (One Health).","authors":"Harald Matthes, Erik W Baars, Benno Brinkhaus, Moritz Christoph, Friedrich Edelhäuser, Christian Grah, Carsten Gründemann, Christian Keßler, David Martin, Andreas Michalsen, Bernd Rosslenbroich, Jana Siroka, Georg Soldner, Michael Teut, Jan Vagedes, Stefan N Willich","doi":"10.1159/000540226","DOIUrl":"10.1159/000540226","url":null,"abstract":"<p><strong>Background: </strong>Considering the analogies between the disruption in ecological systems and in individuals, the concept of integrative medicine is extended to the One Health concept and integrative medicine is introduced as an innovative model for guidance/correction in patients' therapy as well as in ecological realignment.</p><p><strong>Summary: </strong>The specific elements of integrative medicine that can be applied to human health as well as to environmental health are described (e.g. self-regulation, salutogenic healing processes, transdisciplinary multimodal approaches, methodological pluralism). The need for sustainable use of limited resources in medicine and pharmacy is pointed out. As examples for urgent action, the need of taking into account the whole life cycle of pharmaceutical products as well as the impact of diet for human and planetary health are mentioned.</p><p><strong>Key message: </strong>Self-regulation plays a crucial role in human and environmental health; sustainable promotion of self-regulation enables people to become co-creators of their own health. Such a fundamental change requires transformation of one's inner relationship to nature and to oneself. The aim of the mini-review was to concretize individual fields of action and to investigate the question of whether the concepts of integrative medicine can be transferred from humans to the environment and thus to planetary health and whether this makes sense.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}