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Society Bulletins · Gesellschaftsmitteilungen. 学会公告 - 学会公告。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-11-15 DOI: 10.1159/000542372
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引用次数: 0
A difference has been made…. 与众不同....
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-11-12 DOI: 10.1159/000542512
Frauke Musial
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引用次数: 0
Efficacy of Static Magnetic Field Therapy on Pain Intensity, Functional Disability, Sleep Quality and Depressive Symptoms in Patients with Mechanical Neck and Low Back Pain. 静态磁场疗法对机械性颈痛和腰痛患者的疼痛强度、功能障碍、睡眠质量和抑郁症状的疗效。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-11-07 DOI: 10.1159/000542327
Onur Serdar Gencler, Duran Berker Cemil

Introduction: Mechanical neck pain (MNP) and mechanical low back pain (MLBP) can have a negative impact on the quality of life of patients and may be associated with high levels of disability. Magnetic field therapy has been using in the treatment of various diseases. This study was conducted to assess the effects of Static Magnetic Field (SMF) therapy generated by neodymium magnets in patients with MNP and MLBP.

Methods: In this randomized, double-blind, sham-controlled, crossover study, patients with MNP and MLBP were randomly assigned to either the magnetic band or sham band treatment groups. After the initial 2-week phase (with participants randomly assigned to either treatment or sham-control), both groups underwent a 1-week washout period. Subsequently, the groups were swapped and proceeded with a second 2-week phase. Visual Analogue Scale (VAS), Oswestry Low Back Pain Disability Questionnaire (ODI), Neck Disability Index (NDI), Insomnia Severity Index (ISI), and Patient Health Questionnaire-9 (PHQ-9) were used to evaluate the patients' pain severity, functional disability, sleep quality, and levels of depressive symptoms, respectively.

Results: Of the 30 subjects, 17 (56.7%) had MLBP, whereas 13 (43.3%) had MNP. Magnetic band treatment (MBT) resulted in a significant decrease in the VAS score (p < 0.001) in all patients. MBT led to a significant decrease in the ODI score (p = 0.009) in patients with MLBP. A significant decrease in the NDI score was found in MBT (p < 0.001) in patients with MNP. The improvement in ISI and PHQ-9 scores was also significantly higher in MBT (p < 0.001).

Conclusion: For patients with MNP and MLBP who have not experienced sufficient benefits from conventional treatments, neodymium magnets can be considered as an alternative treatment option due to their significant properties.

简介机械性颈痛(MNP)和机械性腰背痛(MLBP)会对患者的生活质量产生负面影响,并可能导致高度残疾。磁场疗法已被用于治疗各种疾病。本研究旨在评估由钕磁铁产生的静态磁场疗法(SMF)对 MNP 和 MLBP 患者的影响:在这项随机、双盲、假对照、交叉研究中,MNP 和 MLBP 患者被随机分配到磁带或假磁带治疗组。在为期两周的初始阶段(参与者被随机分配到治疗组或假对照组)后,两组患者都经历了为期一周的冲洗期。随后,两组对调,进行第二个为期两周的阶段。采用视觉模拟量表(VAS)、Oswestry 腰痛残疾问卷(ODI)、颈部残疾指数(NDI)、失眠严重程度指数(ISI)和患者健康问卷-9(PHQ-9)分别评估患者的疼痛严重程度、功能障碍、睡眠质量和抑郁症状水平:30名受试者中,17人(56.7%)患有MLBP,13人(43.3%)患有MNP。磁带治疗(MBT)使所有患者的 VAS 评分显著下降(p < 0.001)。磁带治疗使 MLBP 患者的 ODI 评分明显下降(p = 0.009)。MNP患者的MBT使NDI评分明显下降(p < 0.001)。MBT患者的ISI和PHQ-9评分也有明显改善(p < 0.001):结论:对于传统治疗方法疗效不佳的颅内压增高症和颅内压增高症患者,钕磁铁因其显著的特性,可被视为一种替代治疗方法。
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引用次数: 0
The effect of acupressure on chemotherapy-induced anxiety and depression: A systematic review and meta-analysis. 穴位按摩对化疗引起的焦虑和抑郁的影响:系统回顾与荟萃分析。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-10-17 DOI: 10.1159/000542022
Chunping Zhang, Jian Chen, Yiwen Zhang, Chuanzhu Yan

Background: Cancer patients are prone to experiencing negative emotions such as anxiety and depression after receiving chemotherapy. Research has shown that acupressure may be beneficial in relieving the anxiety and depression caused by chemotherapy, but high-quality evidence is lacking. This study was designed to systematically evaluate the efficacy of acupressure for relieving chemotherapy-induced anxiety and depression.

Methods: This review was conducted in accordance with the PRISMA framework. Four English databases (PubMed, Embase, Web of Science, and the Cochrane Library) and four Chinese databases (CNKI, Wanfang, VIP, and CBM) were searched from inception to December 31, 2022 to identify randomized clinical trials (RCTs) examining the use of acupressure for the treatment of chemotherapy-induced anxiety and depression. Cochrane Review Manager 5.4 and Rstudiowas were used for the meta-analysis.

Results: This meta-analysis included 1,119 patients from 12 randomized controlled trials. We mainly compared acupressure with sham acupressure and routine nursing. The results showed that acupressure alleviated chemotherapy-induced anxiety (SMD=-0.72, 95% CI[-1.15, 0.28], P=0.001) and depression (SMD=-0.75, 95% CI[-1.36, 0.14], P=0.02) more effectively than sham acupressure and routine nursing.

Conclusion: This meta-analysis found that acupressure (body point) can relieve chemotherapy-induced anxiety and depression and improve the quality of life of patients. However, the current relevant literature has low quality and is highly heterogeneous, which reduces the credibility of the research results. Therefore, more rigorously designed randomized controlled trials are needed to verify these conclusions.

背景:癌症患者在接受化疗后容易出现焦虑和抑郁等负面情绪。研究表明,穴位按摩可有效缓解化疗引起的焦虑和抑郁,但目前尚缺乏高质量的证据。本研究旨在系统评估穴位按摩对缓解化疗引起的焦虑和抑郁的疗效:本综述按照 PRISMA 框架进行。检索了四个英文数据库(PubMed、Embase、Web of Science 和 Cochrane Library)和四个中文数据库(CNKI、万方、VIP 和 CBM),检索时间从开始到 2022 年 12 月 31 日,目的是找出研究穴位按摩治疗化疗引起的焦虑和抑郁的随机临床试验(RCT)。荟萃分析使用了 Cochrane Review Manager 5.4 和 Rstudiowas:这项荟萃分析包括 12 项随机对照试验中的 1,119 名患者。我们主要比较了穴位按摩与假穴位按摩和常规护理。结果显示,与假穴位按摩和常规护理相比,穴位按摩能更有效地缓解化疗引起的焦虑(SMD=-0.72,95% CI[-1.15,0.28],P=0.001)和抑郁(SMD=-0.75,95% CI[-1.36,0.14],P=0.02):本荟萃分析发现,穴位按摩(体表穴位)可以缓解化疗引起的焦虑和抑郁,改善患者的生活质量。然而,目前的相关文献质量不高,异质性较强,降低了研究结果的可信度。因此,需要更严格设计的随机对照试验来验证这些结论。
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引用次数: 0
Investigation of Herbal Therapy Methods Used by Parents of Children with Cancer for Symptom Management in Chemotherapy Process. 癌症患儿家长在化疗过程中使用草药治疗方法控制症状的调查。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-10-04 DOI: 10.1159/000541708
Nurcan Erbay, Nejla Canbulat Sahiner, Mehmet Fatih Aydın

Introduction: The number of types of cancer, which is the leading severe health problem and is frequently seen in childhood period, has steadily increased over the years. This descriptive and cross-sectional study was conducted to determine the herbal treatment methods used by parents of children with cancer during the chemotherapy process for symptom management.

Methods: The study was carried out with the parents of 126 children diagnosed with cancer. The data were collected with a questionnaire form created in line with the literature and the form for the amount and frequency of use of herbal treatment methods used by parents. The data were evaluated with descriptive statistics and χ2 test.

Results: The mean age of the children included in the study was 8.08 ± 3.15 (min = 3, max = 17) years, and the mean duration of diagnosis was 14.35 ± 13.22 (min = 6, max = 60) months. 78.6% (n = 99) of the parents included in the study stated that they used herbal treatment for the treatment of their child's disease. 79.4% (n = 100) of the parents thought that the herbal treatment they used was effective. The first reason (48.4%, n = 61) for using herbal treatment was "to do everything we could for the treatment."

Conclusion: It was determined that the use of herbal treatment methods was related to the mother's profession, the education level of the parents, and the place of residence. In particular, it is necessary to inform parents about herbal treatment methods through nurses with up-to-date information and to create the right attitude toward this issue.

导 言癌症是儿童时期常见的严重健康问题,其类型数量近年来稳步增加。这项描述性横断面研究旨在了解癌症患儿父母在化疗过程中为控制症状而使用的草药治疗方法:研究对象为 126 名癌症患儿的家长。根据文献和家长使用草药治疗方法的数量和频率制作的调查表收集数据。通过描述性统计和卡方检验对数据进行了评估:参与研究的儿童平均年龄为(8.08±3.15)岁(最小=3 岁,最大=17 岁),平均诊断时间为(14.35±13.22)个月(最小=6 个月,最大=60 个月)。78.6%(n=99)的参与研究的家长表示,他们使用中草药治疗孩子的疾病。79.4%(n=100)的家长认为他们使用的中草药治疗有效。使用中草药治疗的首要原因(48.4%,n=61)是 "尽一切可能进行治疗":结论:使用草药治疗方法与母亲的职业、父母的教育水平和居住地有关。特别是,有必要通过护士向家长介绍草药治疗方法的最新信息,并树立对这一问题的正确态度。
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引用次数: 0
Acupuncture in Treating Osteopenia: A Multicenter, Randomized, Controlled Clinical Trial. 针灸治疗骨质疏松症:一项多中心、随机对照临床试验。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-26 DOI: 10.1159/000541440
Yidan Chen, Huaping Qiu, Lihua Xuan, Yabei Jin, Ruixiang Chen, Shitian Teng, Xiaoqing Jin

Introduction: The aim of this study was to analyze the effectiveness of acupuncture as an early intervention in the treatment of osteoporosis and prevention of osteoporosis.

Methods: This multicenter, randomized, controlled clinical trial was conducted in 226 patients with osteoporosis for 6 months. Participants were randomized to the control group (n = 110) and the acupuncture group (n = 116), both groups received basic treatment with daily calcium carbonate and vitamin D3 tablet (containing calcium 600 mg/tablet) supplementation (n = 116), and the acupuncture group received additional acupuncture treatment. Bone mineral density (BMD), Berg Balance Scale (BBS), bone metabolism indexes, and lower limb muscle strength and balance indexes were tested to evaluate the therapy outcomes of the two groups.

Results: After 6 months of treatment, BBS11 (p = 0.046), BBS12 (p = 0.042), and total BBS scores (p = 0) in the acupuncture group were significantly higher than those before treatment; comparing between groups, BBS8 in the acupuncture group was higher than that in the control group after 3 and 6 months, with statistically significant differences (p = 0.036 and 0.0270). After 6 months of treatment, the total BBS score of the acupuncture group was significantly higher than that of the control group, and the difference was statistically significant (p = 0.039). After 6 months of treatment, the BMD of total bone of femoral neck (p = 0.031) and hip joint (p = 0.013) in the acupuncture group was significantly higher than that before treatment, but there was no statistical difference with the control group. The time of five sit-to-stand test (FTSST) was shortened in the acupuncture group, and the difference was statistically significant (p = 0.023), but there was no significant change in the control group (p > 0.05). In addition, the specific sequences of blood phosphorus (p = 0.007), β-collagen (p = 0.009), and N-osteocalcin (p = 0.007) were significantly lower than before treatment after 3 months of acupuncture treatment, and the blood phosphorus level continued to decrease after 6 months of treatment (p = 0.007). In addition, the levels of N-osteocalcin in the acupuncture group were significantly lower than those in the control group after 3 months of treatment (p = 0.008).

Conclusion: Acupuncture can increase hip bone density, improve bone metabolism, reduce bone turnover rate, and improve body balance and lower limb muscle strength in patients with osteoporosis.

引言分析针灸作为早期干预治疗骨质疏松症和预防骨质疏松症的有效性:这项多中心、随机对照临床试验在 226 名骨质疏松症患者中进行,为期 6 个月。将参与者随机分为对照组(n=110)和针灸组(n=116),两组均接受每天补充碳酸钙和维生素 D3 片剂(含钙 600 毫克/片)的基本治疗(n=116),针灸组接受额外的针灸治疗,检测两组的骨矿密度(BMD)、伯格平衡量表(BBS)、骨代谢指标、下肢肌力和平衡指标,以评估两组的治疗效果:治疗6个月后,针灸组的BBS11(P=0.046)、BBS12(P=0.042)和BBS总分(P=0)均明显高于治疗前;组间比较,针灸组的BBS8在3个月和6个月后均高于对照组,差异有统计学意义(P=0.036和0.0270)。治疗 6 个月后,针灸组的 BBS 总分明显高于对照组,差异有统计学意义(P=0.039)。治疗 6 个月后,针灸组股骨颈总骨量(P=0.031)和髋关节总骨量(P=0.013)明显高于治疗前,但与对照组无统计学差异。针刺组五次坐立试验(FTSST)时间缩短,差异有统计学意义(P=0.023),但对照组无明显变化(P>0.05)。此外,针灸治疗 3 个月后,血磷(p=0.007)、β-胶原(p=0.009)和 N-骨钙素(p=0.007)的特异性序列明显低于治疗前,治疗 6 个月后血磷水平继续下降(p=0.007)。此外,针灸治疗 3 个月后,针灸组的 N-骨钙素水平明显低于对照组(P=0.008):针灸可增加骨质疏松症患者的髋关节骨密度,改善骨代谢,降低骨转换率,改善身体平衡和下肢肌肉力量。
{"title":"Acupuncture in Treating Osteopenia: A Multicenter, Randomized, Controlled Clinical Trial.","authors":"Yidan Chen, Huaping Qiu, Lihua Xuan, Yabei Jin, Ruixiang Chen, Shitian Teng, Xiaoqing Jin","doi":"10.1159/000541440","DOIUrl":"10.1159/000541440","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to analyze the effectiveness of acupuncture as an early intervention in the treatment of osteoporosis and prevention of osteoporosis.</p><p><strong>Methods: </strong>This multicenter, randomized, controlled clinical trial was conducted in 226 patients with osteoporosis for 6 months. Participants were randomized to the control group (n = 110) and the acupuncture group (n = 116), both groups received basic treatment with daily calcium carbonate and vitamin D3 tablet (containing calcium 600 mg/tablet) supplementation (n = 116), and the acupuncture group received additional acupuncture treatment. Bone mineral density (BMD), Berg Balance Scale (BBS), bone metabolism indexes, and lower limb muscle strength and balance indexes were tested to evaluate the therapy outcomes of the two groups.</p><p><strong>Results: </strong>After 6 months of treatment, BBS11 (p = 0.046), BBS12 (p = 0.042), and total BBS scores (p = 0) in the acupuncture group were significantly higher than those before treatment; comparing between groups, BBS8 in the acupuncture group was higher than that in the control group after 3 and 6 months, with statistically significant differences (p = 0.036 and 0.0270). After 6 months of treatment, the total BBS score of the acupuncture group was significantly higher than that of the control group, and the difference was statistically significant (p = 0.039). After 6 months of treatment, the BMD of total bone of femoral neck (p = 0.031) and hip joint (p = 0.013) in the acupuncture group was significantly higher than that before treatment, but there was no statistical difference with the control group. The time of five sit-to-stand test (FTSST) was shortened in the acupuncture group, and the difference was statistically significant (p = 0.023), but there was no significant change in the control group (p &gt; 0.05). In addition, the specific sequences of blood phosphorus (p = 0.007), β-collagen (p = 0.009), and N-osteocalcin (p = 0.007) were significantly lower than before treatment after 3 months of acupuncture treatment, and the blood phosphorus level continued to decrease after 6 months of treatment (p = 0.007). In addition, the levels of N-osteocalcin in the acupuncture group were significantly lower than those in the control group after 3 months of treatment (p = 0.008).</p><p><strong>Conclusion: </strong>Acupuncture can increase hip bone density, improve bone metabolism, reduce bone turnover rate, and improve body balance and lower limb muscle strength in patients with osteoporosis.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142343039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective adjuvant Ayurvedic treatment modulates immune response and oxidative stress in patient with carcinoma of pyriform fossa, undergoing radiotherapy: A case study. 选择性阿育吠陀辅助治疗可调节接受放疗的梨状窝癌患者的免疫反应和氧化应激:病例研究。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-18 DOI: 10.1159/000541254
Vineeta Deshmukh,Shubhada Chiplunkar,Sadanand Sardeshmukh,Tushar Patil,Jagdish Shinde,Vidya Gupta,Shweta Gujar,Nilambari Sardeshmukh,Shridevi Pathak,Sandeep Chavan,Trupti Pradhan,Jueelee Godbole
Introduction - Hypopharyngeal squamous cell carcinoma has poor prognosis with only 25% chances of 5 years of relative survival in such patients in spite of conventional treatment including radical surgery, radiotherapy and concurrent chemotherapy. Case Presentation - A chronic tobacco - betel nut chewer 62-years-old male patient had dysphagia with hoarseness of voice diagnosed with stage III, grade II malignant pyriform fossa. The patient underwent 9 cycles of neo adjuvant chemotherapy with Inj Paclitaxel 100 mg and Inj Cisplatin 40 mg. He was then referred to our institute for Radical Radiotherapy with Concurrent Chemotherapy with adjunct Ayurvedic treatment. A total dose of 70 Gy of radiation with cobalt 60 source was administered to the bilateral face and neck, in 35 fractions. Patient also received 6 cycles of concurrent weekly chemotherapy with Inj Cisplatin 40 mg. He received well planned adjunct Ayurvedic treatment in the form of Oral Ayurvedic Medicines (OAM) and Detoxifying treatment, Panchakarma. All the measured adverse effects of radiotherapy such as Stomatitis, Xerostomia, Taste Alteration, Dysphagia, Nausea etc. were observed to be remarkably low during and post radiotherapy in this patient. Karnofsky and QoL scores revealed patient's wellbeing throughout the treatment course. After 5 years PET CT scan revealed no FDG avid loco regional recurrence or distant organ involvement implying Disease Free Survival (DFS). Various Chemokines, cytokines and oxidative stress were assessed during the course of treatment to observe tumour microenvironment. Conclusion - Present case of HNC, Stage III and Grade II belonged to high-grade, high-risk hypopharyngeal cancer with poor prognosis. The patient opted for Ayurvedic treatment besides radiotherapy which continued thereafter for 5 years. We therefore emphasize that in this case, minimum side effects of radiotherapy, immunomodulation and reduction in inflammation and oxidative stress along with good quality of life can be attributed to OAM and repeated detoxifying Panchakarma treatment supported with healthy diet and good lifestyle. The highlight of the study is the marked effect on the patient's immune response and reduction in oxidative stress leading to 5 years and beyond of DFS.
导言--下咽鳞状细胞癌的预后较差,尽管采用了根治性手术、放疗和同步化疗等常规治疗方法,但此类患者的相对生存期只有 25%。病例介绍 - 一位长期咀嚼烟草和槟榔的 62 岁男性患者出现吞咽困难和声音嘶哑,被诊断为梨状窝恶性肿瘤 III 期 II 级。患者接受了 9 个周期的新辅助化疗,使用紫杉醇注射液 100 毫克和顺铂注射液 40 毫克。随后,他被转到我院接受根治性放疗,同时接受阿育吠陀辅助化疗。我们使用钴 60 放射源对双侧面部和颈部进行了总剂量为 70 Gy 的放射治疗,共分 35 次进行。患者还同时接受了 6 个周期的化疗,每周使用 40 毫克顺铂。他还接受了计划周密的阿育吠陀辅助治疗,包括口服阿育吠陀药物(OAM)和排毒治疗(Panchakarma)。据观察,该患者在放疗期间和放疗后的口腔炎、口臭、味觉改变、吞咽困难、恶心等放疗不良反应均明显减少。Karnofsky 和 QoL 评分显示患者在整个治疗过程中都很健康。5 年后,正电子发射计算机断层扫描(PET CT)显示没有 FDG 阳性局部区域复发或远处器官受累,这意味着无病生存期(DFS)。在治疗过程中,对各种趋化因子、细胞因子和氧化应激进行了评估,以观察肿瘤微环境。结论--本病例为HNC,Ⅲ期,Ⅱ级,属于高分化、高风险的下咽癌,预后较差。患者除接受放疗外,还选择了阿育吠陀疗法,该疗法持续了 5 年。因此,我们强调,在这个病例中,放疗的副作用最小、免疫调节、炎症和氧化应激减少以及良好的生活质量都归功于 OAM 和反复排毒的 Panchakarma 治疗,并辅以健康的饮食和良好的生活方式。这项研究的亮点在于对患者免疫反应的显著影响以及氧化应激的减少,从而使患者的 DFS 达到 5 年及以上。
{"title":"Selective adjuvant Ayurvedic treatment modulates immune response and oxidative stress in patient with carcinoma of pyriform fossa, undergoing radiotherapy: A case study.","authors":"Vineeta Deshmukh,Shubhada Chiplunkar,Sadanand Sardeshmukh,Tushar Patil,Jagdish Shinde,Vidya Gupta,Shweta Gujar,Nilambari Sardeshmukh,Shridevi Pathak,Sandeep Chavan,Trupti Pradhan,Jueelee Godbole","doi":"10.1159/000541254","DOIUrl":"https://doi.org/10.1159/000541254","url":null,"abstract":"Introduction - Hypopharyngeal squamous cell carcinoma has poor prognosis with only 25% chances of 5 years of relative survival in such patients in spite of conventional treatment including radical surgery, radiotherapy and concurrent chemotherapy. Case Presentation - A chronic tobacco - betel nut chewer 62-years-old male patient had dysphagia with hoarseness of voice diagnosed with stage III, grade II malignant pyriform fossa. The patient underwent 9 cycles of neo adjuvant chemotherapy with Inj Paclitaxel 100 mg and Inj Cisplatin 40 mg. He was then referred to our institute for Radical Radiotherapy with Concurrent Chemotherapy with adjunct Ayurvedic treatment. A total dose of 70 Gy of radiation with cobalt 60 source was administered to the bilateral face and neck, in 35 fractions. Patient also received 6 cycles of concurrent weekly chemotherapy with Inj Cisplatin 40 mg. He received well planned adjunct Ayurvedic treatment in the form of Oral Ayurvedic Medicines (OAM) and Detoxifying treatment, Panchakarma. All the measured adverse effects of radiotherapy such as Stomatitis, Xerostomia, Taste Alteration, Dysphagia, Nausea etc. were observed to be remarkably low during and post radiotherapy in this patient. Karnofsky and QoL scores revealed patient's wellbeing throughout the treatment course. After 5 years PET CT scan revealed no FDG avid loco regional recurrence or distant organ involvement implying Disease Free Survival (DFS). Various Chemokines, cytokines and oxidative stress were assessed during the course of treatment to observe tumour microenvironment. Conclusion - Present case of HNC, Stage III and Grade II belonged to high-grade, high-risk hypopharyngeal cancer with poor prognosis. The patient opted for Ayurvedic treatment besides radiotherapy which continued thereafter for 5 years. We therefore emphasize that in this case, minimum side effects of radiotherapy, immunomodulation and reduction in inflammation and oxidative stress along with good quality of life can be attributed to OAM and repeated detoxifying Panchakarma treatment supported with healthy diet and good lifestyle. The highlight of the study is the marked effect on the patient's immune response and reduction in oxidative stress leading to 5 years and beyond of DFS.","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":"196 1","pages":"1-23"},"PeriodicalIF":1.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin in the treatment of type 2 diabetes mellitus combined with heart failure: a systematic evaluation and meta-analysis based on a randomized controlled trial. 益气活血中药联合达帕格列净治疗 2 型糖尿病合并心力衰竭:基于随机对照试验的系统评价和荟萃分析。
IF 1.8 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-18 DOI: 10.1159/000541234
Changxing Liu,Xinyi Guo,He Wang,Yabin Zhou
INTRODUCTIONThis systematic review examines the efficacy of a combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin in treating type 2 diabetes mellitus (T2DM) combined with heart failure (HF).METHODSRandomized controlled trials (RCTs) assessing the combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin for T2DM and CHF was conducted. The search, spanning from the database's establishment to June 2023, included seven databases: China Knowledge Network (CNKI), Wanfang Database, VIP Database, PubMed, Embase, Cochrane Library, and the Chinese Biomedical Literature Database. Two researchers screened and extracted data based on inclusion and exclusion criteria. The Cochrane Handbook version 5.1 guided the quality assessment of studies, and the meta-analysis was performed using RevMan 5.4 software.RESULTSEleven articles, encompassing a sample size of 1192 cases, were included. Meta-analysis results indicated that combining Qi benefiting and blood circulation promoting herbs with Dapagliflozin improved the clinical efficacy rate [OR=4.35, 95% CI (2.98, 6.35), P<0.00001]. It reduced blood glucose levels, evidenced by decreased fasting blood glucose (FBG) [MD=-1.19, 95% CI (-1.30, -1.09), P<0.00001], 2-hour postprandial blood glucose (2hPG) [MD=-1.95, 95% CI (-2.09, -1.80), P<0.00001], and glycosylated haemoglobin (HbA1c) [MD=-1.40, 95% CI (-1.49, -1.31), P<0.00001]. Inflammatory factors also reduced, including C-reactive protein (CRP) [MD=-4.93, 95% CI (-5.38, -4.48), P<0.00001], tumor necrosis factor (TNF-α) [MD=-2.91, 95% CI (-3.32, -2.49), P<0.00001], and interleukin-6 (IL-6) [MD=-11.10, 95% CI (-12.43, -9.43), P<0.00001]. Additionally, left ventricular end-diastolic diameter (LVEDD) [SMD=-1.25, 95% CI (-1.45, -1.05), P<0.00001], left ventricular end-systolic diameter (LVESD) [SMD=-1.34, 95% CI (-1.51, -1.13), P<0.00001], and improved left ventricular ejection fraction (LVEF)[SMD=2.92, 95% CI (2.65, 3.19), P<0.00001], 6-minute walk test (6MWT) [MD=35.59, 95% CI (29.72, 41.47), P<0.00001], and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores [MD=35.59, 95% CI (29.72, 41.47), P<0.00001] were observed. The incidence of adverse events also decreased [RR=0.25, 95% CI (0.11, 0.56), P=0.0007].CONCLUSIONThe combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin shows potential in treating patients with T2DM and HF, suggesting its use as adjunctive therapy in clinical practice. However, the limited number and quality of the included studies necessitate further high-quality research to confirm these findings.
方法对益气活血中药联合达帕格列净治疗 2 型糖尿病(T2DM)合并心力衰竭(HF)的随机对照试验(RCT)进行了评估。检索时间跨度为数据库建立至 2023 年 6 月,包括 7 个数据库:中国知网(CNKI)、万方数据库、VIP数据库、PubMed、Embase、Cochrane图书馆和中国生物医学文献数据库。两名研究人员根据纳入和排除标准筛选和提取数据。结果共纳入 7 篇文章,样本量为 1192 例。荟萃分析结果表明,益气活血中药与达帕利洛嗪合用可提高临床有效率[OR=4.35,95% CI (2.98,6.35),P<0.00001]。它降低了血糖水平,表现为空腹血糖(FBG)降低[MD=-1.19,95% CI(-1.30,-1.09),P<0.00001],餐后 2 小时血糖(2hPG)降低[MD=-1.95,95% CI(-2.09,-1.80),P<0.00001]和糖化血红蛋白(HbA1c)[MD=-1.40,95% CI(-1.49,-1.31),P<0.00001]。炎症因子也有所降低,包括C反应蛋白(CRP)[MD=-4.93,95% CI(-5.38,-4.48),P<0.00001]、肿瘤坏死因子(TNF-α)[MD=-2.91,95% CI(-3.32,-2.49),P<0.00001]和白细胞介素-6(IL-6)[MD=-11.10,95% CI(-12.43,-9.43),P<0.00001]。此外,左心室舒张末期直径(LVEDD)[SMD=-1.25,95% CI(-1.45,-1.05),P<0.00001]、左心室收缩末期直径(LVESD)[SMD=-1.34,95% CI(-1.51,-1.13),P<0.00001]和左心室射血分数(LVEF)[SMD=2.92,95% CI (2.65,3.19),P<0.00001]、6分钟步行测试(6MWT)[MD=35.59,95% CI (29.72,41.47),P<0.00001]和明尼苏达心衰患者生活问卷(MLHFQ)评分[MD=35.59,95% CI (29.72,41.47),P<0.00001]均有所改善。结论益气活血中药与达帕利洛嗪联合治疗T2DM合并HF患者显示出潜力,建议在临床实践中作为辅助治疗使用。然而,由于纳入研究的数量和质量有限,有必要进一步开展高质量的研究来证实这些发现。
{"title":"Combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin in the treatment of type 2 diabetes mellitus combined with heart failure: a systematic evaluation and meta-analysis based on a randomized controlled trial.","authors":"Changxing Liu,Xinyi Guo,He Wang,Yabin Zhou","doi":"10.1159/000541234","DOIUrl":"https://doi.org/10.1159/000541234","url":null,"abstract":"INTRODUCTIONThis systematic review examines the efficacy of a combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin in treating type 2 diabetes mellitus (T2DM) combined with heart failure (HF).METHODSRandomized controlled trials (RCTs) assessing the combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin for T2DM and CHF was conducted. The search, spanning from the database's establishment to June 2023, included seven databases: China Knowledge Network (CNKI), Wanfang Database, VIP Database, PubMed, Embase, Cochrane Library, and the Chinese Biomedical Literature Database. Two researchers screened and extracted data based on inclusion and exclusion criteria. The Cochrane Handbook version 5.1 guided the quality assessment of studies, and the meta-analysis was performed using RevMan 5.4 software.RESULTSEleven articles, encompassing a sample size of 1192 cases, were included. Meta-analysis results indicated that combining Qi benefiting and blood circulation promoting herbs with Dapagliflozin improved the clinical efficacy rate [OR=4.35, 95% CI (2.98, 6.35), P&lt;0.00001]. It reduced blood glucose levels, evidenced by decreased fasting blood glucose (FBG) [MD=-1.19, 95% CI (-1.30, -1.09), P&lt;0.00001], 2-hour postprandial blood glucose (2hPG) [MD=-1.95, 95% CI (-2.09, -1.80), P&lt;0.00001], and glycosylated haemoglobin (HbA1c) [MD=-1.40, 95% CI (-1.49, -1.31), P&lt;0.00001]. Inflammatory factors also reduced, including C-reactive protein (CRP) [MD=-4.93, 95% CI (-5.38, -4.48), P&lt;0.00001], tumor necrosis factor (TNF-α) [MD=-2.91, 95% CI (-3.32, -2.49), P&lt;0.00001], and interleukin-6 (IL-6) [MD=-11.10, 95% CI (-12.43, -9.43), P&lt;0.00001]. Additionally, left ventricular end-diastolic diameter (LVEDD) [SMD=-1.25, 95% CI (-1.45, -1.05), P&lt;0.00001], left ventricular end-systolic diameter (LVESD) [SMD=-1.34, 95% CI (-1.51, -1.13), P&lt;0.00001], and improved left ventricular ejection fraction (LVEF)[SMD=2.92, 95% CI (2.65, 3.19), P&lt;0.00001], 6-minute walk test (6MWT) [MD=35.59, 95% CI (29.72, 41.47), P&lt;0.00001], and Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores [MD=35.59, 95% CI (29.72, 41.47), P&lt;0.00001] were observed. The incidence of adverse events also decreased [RR=0.25, 95% CI (0.11, 0.56), P=0.0007].CONCLUSIONThe combination of Qi benefiting and blood circulation promoting herbs with Dapagliflozin shows potential in treating patients with T2DM and HF, suggesting its use as adjunctive therapy in clinical practice. However, the limited number and quality of the included studies necessitate further high-quality research to confirm these findings.","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":"64 1","pages":"1-28"},"PeriodicalIF":1.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Maintenance Treatment of a Patient with Resistant Hyperthyroidism with Traditional Persian Medicine Recommendations: A Case Report and Literature Review. 用传统波斯医学建议成功维持治疗一名抗药性甲状腺功能亢进症患者:病例报告和文献综述。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-05 DOI: 10.1159/000541255
Mohammad Mahdi Parvizi, Sara Foolad, Ali Zeighami, Mohammad Reza Namazi, Mojtaba Heydari

Introduction: Hyperthyroidism is a common endocrinology condition that could affect several aspects of the patient's life.

Case presentation: We present a 27-year-old woman who was sent to the traditional Persian medicine (TPM) clinic with a diagnosis of uncontrolled chronic hyperthyroidism (lower levels of thyroid-stimulating hormone (TSH) and higher levels of T3 and T4) and its complications, such as developing exophthalmos, palpitations, anxiety, sleep problems, hair loss, and dry skin. The patient was under treatment with prednisolone and methimazole for up to 1 year, but no acceptable improvement was achieved. The patient received a package of TPM recommendations, which included lifestyle modification, Melissa officinalis herbal tea, and Persian barley water. The patient was followed for 1 year. After 2 months of follow-up of the patient, the level of TSH increased, and the level of T3 and T4 decreased. In addition, the patient's symptoms, including exophthalmos, palpitation, anxiety, sleep disturbance, and dryness of the skin, were improved considerably. After 3 months of consumption of the TPM-based regime and prescription, the serum levels of TSH, T3, and T4, of the patient were in normal ranges. In a 1-year follow-up of the patient, the patient's condition was stable and her thyroid function tests were normal. We hereby present the following case to be in line with the CAse REports (CARE) checklist.

Conclusion: It appears that TPM lifestyle recommendations, M. officinalis herbal tea, and Persian barley water were effective in treating the patient with uncontrolled hyperthyroidism. We recommend further studies and clinical trial designs in this regard.

简介甲状腺功能亢进症是一种常见的内分泌疾病,可能会影响患者生活的多个方面:我们为您介绍一位 27 岁的女性患者,她被送往传统波斯医学(TPM)诊所就诊,被诊断为不受控制的慢性甲状腺功能亢进症(促甲状腺激素(TSH)水平较低,T3 和 T4 水平较高)及其并发症,如眼球外翻、心悸、焦虑、睡眠问题、脱发和皮肤干燥。患者接受了长达一年的泼尼松龙和甲巯咪唑治疗,但病情没有得到可接受的改善。患者接受了一整套 TPM 建议,包括改变生活方式、香蜂草凉茶和波斯大麦水。对患者进行了为期一年的随访。随访两个月后,患者的促甲状腺激素水平上升,T3 和 T4 水平下降。此外,患者的眼球外翻、心悸、焦虑、睡眠障碍和皮肤干燥等症状也得到了明显改善。在服用基于 TPM 的疗法和处方三个月后,患者血清中的促甲状腺激素、T3 和 T4 水平均处于正常范围。在对患者一年的随访中,患者病情稳定,甲状腺功能检测正常。我们在此提出以下病例,以符合CAse REports(CARE)检查表的要求:结论:看来,TPM生活方式建议、香蜂草凉茶和波斯大麦水对治疗该名不受控制的甲状腺功能亢进症患者很有效。我们建议在这方面开展进一步的研究和临床试验设计。
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引用次数: 0
Severe Itch Related to Hard Workload Treated with Acupuncture: Unexpected Results - A Case report. 针灸治疗与工作量大有关的严重瘙痒。意想不到的效果。病例报告。
IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-09-02 DOI: 10.1159/000541191
Lisbeth Dahlin, Anja Finn

Introduction: The effects of work-related stress (WRS) on occupational health often lead to reduced well-being and long-term sick leave. Itching or pruritus, a skin inflammation with a rash that provokes the desire to scratch, often occurs during stressful periods in patients with a history of atopic dermatitis (AD).

Case presentation: This patient suffered from severe WRS together with long-term therapeutically resistant pruritus for 8 years, resulting in severe itching. He was provided with an intervention with acupuncture treatment (AT) to prevent a long-term sick leave. The results showed an unexpected reduction in itching, skin inflammation, and eczema. Additionally, the treatment enhanced the patient's emotional and cognitive well-being and eliminated the need for sick leave.

Conclusion: Acupuncture can be an effective complementary treatment for severe itching related to WRS, in addition to standard medical treatments.

简介与工作有关的压力(WRS)对职业健康的影响往往会导致幸福感下降和长期病假。瘙痒或瘙痒症是一种皮肤炎症,伴有皮疹,会引起搔抓的欲望,经常发生在有特应性皮炎(AD)病史的患者身上:病例介绍:这位患者患有严重的 WRS,并伴有长期治疗耐受性瘙痒症,导致严重瘙痒长达八年之久。为了防止长期病假,他接受了针灸治疗(AT)干预。结果显示,瘙痒、皮肤炎症和湿疹出乎意料地减轻了。此外,治疗还增强了患者的情绪和认知能力,使其不再需要请病假:结论:针灸可作为标准医疗方法之外的一种有效辅助治疗方法,用于治疗与 WRS 相关的严重瘙痒。
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引用次数: 0
期刊
Complementary Medicine Research
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