Polymorphisms in the Renin-Angiotensin System and eNOS Glu298Asp Genes Are Associated with Increased Risk for Essential Hypertension in a Mexican Population.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2023-01-01 DOI:10.1155/2023/4944238
Irma Isordia-Salas, David Santiago-Germán, Alejandro Flores-Arizmendi, Alfredo Leaños-Miranda
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Abstract

Background: Essential hypertension is the result of modifiable and genetic factors, and it is associated with increased risk for atherothrombosis. Some polymorphisms are associated with hypertensive disease. The objective was to analyze the association between eNOS Glu298Asp, MTHR C677T, AGT M235T, AGT T174M, and A1166C and ACE I/D polymorphisms with essential hypertension in the Mexican population.

Materials and methods: In the present study, 224 patients with essential hypertension and 208 subjects without hypertension were included. The Glu298Asp, C677T, M235T, T174M, A1166C, and I/D polymorphisms were determined by the PCR-RFLP technique.

Results: We found statistical differences in age, gender, BMI, systolic and diastolic blood pressure, and total cholesterol between control and cases. However, we found no significant differences in HbA1c and triglycerides between both groups. We observed statistical significant differences in the genotype distribution of Glu298Asp (P = 0.001), I/D (P = 0.02), and M235T (P = 0.004) polymorphisms between both groups. In contrast, there were no differences related to distribution of genotypes of MTHFR C677T (P = 0.12), M174T (P = 0.46), and A1166C (P = 0.85) between cases and control groups.

Conclusions: We identified that Glu298Asp, I/D, and M234T polymorphisms represented an increased risk for essential hypertension and those genetic variants could contribute to the presence of endothelial dysfunction and vasopressor effect, hyperplasia, and hypertrophy of smooth muscle cells, which had an impact for hypertension. In contrast, we found no association between C677C, M174T, and A1166C polymorphisms and hypertensive disease. We suggested that those genetic variants could be identified in individuals with high risk to avoid hypertension and thrombotic disease.

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肾素-血管紧张素系统和eNOS Glu298Asp基因多态性与墨西哥人群原发性高血压风险增加相关
背景:原发性高血压是可改变和遗传因素的结果,它与动脉粥样硬化血栓形成的风险增加有关。一些多态性与高血压疾病有关。目的是分析eNOS Glu298Asp、MTHR C677T、AGT M235T、AGT T174M和A1166C以及ACE I/D多态性与墨西哥人群原发性高血压的关系。材料与方法:本研究纳入原发性高血压患者224例,非高血压患者208例。采用PCR-RFLP技术检测Glu298Asp、C677T、M235T、T174M、A1166C和I/D多态性。结果:我们发现对照组和病例在年龄、性别、BMI、收缩压和舒张压以及总胆固醇方面存在统计学差异。然而,我们发现两组之间HbA1c和甘油三酯没有显著差异。两组间Glu298Asp (P = 0.001)、I/D (P = 0.02)、M235T (P = 0.004)多态性基因型分布差异均有统计学意义。而MTHFR C677T (P = 0.12)、M174T (P = 0.46)、A1166C (P = 0.85)基因型分布在病例组与对照组之间无差异。结论:我们发现Glu298Asp、I/D和M234T基因多态性增加了原发性高血压的风险,这些基因变异可能导致内皮功能障碍和血管加压作用、平滑肌细胞增生和肥大,从而对高血压产生影响。相反,我们发现C677C、M174T和A1166C多态性与高血压疾病没有关联。我们认为这些基因变异可以在高危人群中发现,以避免高血压和血栓性疾病。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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