Assessment of hypolipidemic and anti-inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-induced hyperlipidemia in rat kidney, liver, and heart

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Recognition Pub Date : 2022-12-20 DOI:10.1002/jmr.3004

Esra Palabıyık, Ayşe Nurseli Sulumer, Handan Uguz, Bahri Avcı, Seda Askın, Hakan Askın, Yeliz Demir

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引用次数: 13

Abstract

Atherosclerosis and cognitive impairment are both influenced by hyperlipidemia. Due to their high margin of safety and low cost, natural chemicals have recently attracted particular attention in the context of the treatment of disease. Hence, the purpose of this study was to investigate the possible amendatory impact of ethanol extract walnut (Juglans regia) seed coat (E-WSC) on some metabolic enzymes (glutathione reductase (GR), paraoxonase-1 (PON1), aldose reductase (AR), sorbitol dehydrogenase (SDH), acetylcholinesterase (AChE), glutathione S-transferase (GST), and butyrylcholinesterase (BChE)) activity in the liver, kidney, and heart of rats with Triton WR-1339-induced hyperlipidemia. Rats were divided into five groups: control group, HL-Control group (Triton WR-1339 400 mg/kg, i.p administered group), E- WSC + 150 (150 mg/kg,o.d given group), E- WSC + 300 (E- WSC 300 mg/kg, o.d given group) and HL+ E-WSC + 300 (Group receiving E- WSC 300 mg/kg, o.d 30 min prior to administration of Triton WR-1339 400 mg/kg, i.p). In HL-Control, AR, SDH, and BChE enzyme activity was significantly increased in all tissues compared to the control, while the activity of other studied enzymes was significantly decreased. The effects of hyperlipidemia on balance were improved and alterations in the activity of the investigated metabolic enzymes were prevented by E-WSC. As a result, promising natural compounds that can be used as adjuvant therapy in the treatment of cognitive disorders and hyperlipidemia may be found in E-WSC powder.

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核桃种皮提取物的降血脂和抗炎特性及对triton wr -1339诱导的大鼠肾、肝和心脏高脂血症代谢酶活性的调节作用

动脉粥样硬化和认知障碍均受高脂血症的影响。由于其高安全边际和低成本，天然化学品最近在疾病治疗方面引起了特别关注。因此，本研究旨在探讨乙醇提取物核桃种皮(E-WSC)对Triton wr -1339诱导的高脂血症大鼠肝脏、肾脏和心脏代谢酶(谷胱甘肽还原酶(GR)、对氧磷酶-1 (PON1)、醛糖还原酶(AR)、山梨糖醇脱氢酶(SDH)、乙酰胆碱酯酶(AChE)、谷胱甘肽s -转移酶(GST)和丁基胆碱酯酶(BChE))活性的可能调节作用。将大鼠分为5组:对照组、hl -对照组(Triton WR-1339 400 mg/kg, ig给药组)、E- WSC + 150 (150 mg/kg, 0。d给药组)、E-WSC + 300 (E- WSC 300 mg/kg，每日给药组)和HL+ E-WSC + 300 (E- WSC 300 mg/kg组，每日给药前30分钟给予Triton WR-1339 400 mg/kg, i.p)。在HL-Control中，所有组织中AR、SDH和BChE酶活性均显著高于control，而其他酶活性均显著降低。E-WSC改善了高脂血症对平衡的影响，并阻止了所研究代谢酶活性的改变。因此，在E-WSC粉中可能会发现有希望用作辅助治疗认知障碍和高脂血症的天然化合物。

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来源期刊

Journal of Molecular Recognition 生物-生化与分子生物学

CiteScore

4.60

自引率

3.70%

发文量

审稿时长

2.7 months

期刊介绍： Journal of Molecular Recognition (JMR) publishes original research papers and reviews describing substantial advances in our understanding of molecular recognition phenomena in life sciences, covering all aspects from biochemistry, molecular biology, medicine, and biophysics. The research may employ experimental, theoretical and/or computational approaches. The focus of the journal is on recognition phenomena involving biomolecules and their biological / biochemical partners rather than on the recognition of metal ions or inorganic compounds. Molecular recognition involves non-covalent specific interactions between two or more biological molecules, molecular aggregates, cellular modules or organelles, as exemplified by receptor-ligand, antigen-antibody, nucleic acid-protein, sugar-lectin, to mention just a few of the possible interactions. The journal invites manuscripts that aim to achieve a complete description of molecular recognition mechanisms between well-characterized biomolecules in terms of structure, dynamics and biological activity. Such studies may help the future development of new drugs and vaccines, although the experimental testing of new drugs and vaccines falls outside the scope of the journal. Manuscripts that describe the application of standard approaches and techniques to design or model new molecular entities or to describe interactions between biomolecules, but do not provide new insights into molecular recognition processes will not be considered. Similarly, manuscripts involving biomolecules uncharacterized at the sequence level (e.g. calf thymus DNA) will not be considered.