Nonenzymatic hydrolysis reactions of adenosine 5′-triphosphate and its related compounds—III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis
{"title":"Nonenzymatic hydrolysis reactions of adenosine 5′-triphosphate and its related compounds—III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis","authors":"Shinnichiro Suzuki , Tadayoshi Higashiyama , Akitsugu Nakahara","doi":"10.1016/S0006-3061(00)80162-3","DOIUrl":null,"url":null,"abstract":"<div><p>Trichlorodiethylenetriaminecobalt(III), [CoCl<sub>3</sub>dien], which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic mode, accelerated effectively and specifically hydrolysis of ATP to ADP and Pi. A kinetic study of the reaction indicated that the rate of hydrolysis was first order with respect to the concentration of ATP in the presence of an excess of [CoCl<sub>3</sub>dien]. The rate constant was calculated to be 1.05 × 10<sup>−2</sup> min<sup>−1</sup> at pH 4.0 (50°C), corresponding to a catalysis of the hydrolysis of ATP by a factor of 150. The complex possessing one good</p></div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 4","pages":"Pages 277-289"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80162-3","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinorganic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0006306100801623","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
Trichlorodiethylenetriaminecobalt(III), [CoCl3dien], which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic mode, accelerated effectively and specifically hydrolysis of ATP to ADP and Pi. A kinetic study of the reaction indicated that the rate of hydrolysis was first order with respect to the concentration of ATP in the presence of an excess of [CoCl3dien]. The rate constant was calculated to be 1.05 × 10−2 min−1 at pH 4.0 (50°C), corresponding to a catalysis of the hydrolysis of ATP by a factor of 150. The complex possessing one good