A randomized combination chemotherapy trial, with and without adriamycin, in squamous cell carcinoma of the head and neck.

H J Shaw, L A Price, B T Hill, A H Calvert, V M Dalley, A Levene
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引用次数: 6

Abstract

One hundred seventeen patients with advanced squamous cell carcinoma of the head and neck were treated and placed randomly between two combination protocols, one with adriamycin and the other without. Responses (more than 50% tumor regression) were 67% overall with 63% responding to the combination without adriamycin and 82% responding to the protocol containing it. The increase in the response rate seen with the addition of adriamycin was not statistically significant. The degree of response to chemotherapy was reduced by prior radiotherapy.

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一项随机联合化疗试验,用或不用阿霉素,头颈部鳞状细胞癌。
117例晚期头颈部鳞状细胞癌患者接受了治疗,并随机分为两组,一组使用阿霉素,另一组不使用阿霉素。总体反应(超过50%的肿瘤消退)为67%,其中63%对不含阿霉素的联合治疗有反应,82%对含阿霉素的方案有反应。添加阿霉素后反应率的增加没有统计学意义。化疗的反应程度因先前的放疗而降低。
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