Rheumatoid factor appearance in Micrococcus lysodeikticus immunization and its interference with allotype specific reactions.

R Hamers, C Hamers-Casterman, W van der Loo, A D Strosberg, P De Baetselier
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引用次数: 0

Abstract

Rabbits hyperimmunized with Micrococcus lysodeikticus produce, in addition to anti-cell wall antibodies, considerable amounts of anti-immunoglobulins or rheumatoid factors which can interfere with immune reactions. In particular, in immunodiffusion, they can reveal non precipitating systems for which the immunodiffusion typing sera are usually not tested. In our hands, rabbit allotypes d12 and A8 give rise to visible immunodiffusion reactions in presence of rheumatoid factors. Inhibition of this reaction can be used to type for these markers in sera which do not contain the rheumatoid factors.

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溶血微球菌免疫过程中类风湿因子的出现及其对同种异型特异性反应的干扰。
用溶血微球菌过度免疫的兔子,除了产生抗细胞壁抗体外,还产生相当数量的抗免疫球蛋白或类风湿因子,这些因子可以干扰免疫反应。特别是,在免疫扩散中,它们可以揭示通常不检测免疫扩散分型血清的非沉淀系统。在我们的研究中,兔同种异体d12和A8在类风湿因子存在的情况下引起可见的免疫扩散反应。抑制这种反应可用于在不含类风湿因子的血清中对这些标记物进行分型。
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