E P Rieber, J G Saal, G Riethmüller, H W Heyden, H D Waller
{"title":"Strong expression of Fc-receptors on leukemic cells in hairy cell leukemia.","authors":"E P Rieber, J G Saal, G Riethmüller, H W Heyden, H D Waller","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fc-receptor actitivy on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of 125I-labelled aggregated IgG under saturation conditions, it was found that the hariy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound 125I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4 degrees C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20 degrees C.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"151 3","pages":"282-8"},"PeriodicalIF":0.0000,"publicationDate":"1976-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fc-receptor actitivy on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of 125I-labelled aggregated IgG under saturation conditions, it was found that the hariy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound 125I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4 degrees C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20 degrees C.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
