Correlation between the results of the migration inhibitory factor production test with DNA and the severity of the disease in the systemic lupus erythematosus patients.

J Rovenský, J Svejcar, J Pekárek, D Zitnan, O Hajzok, L Cebecauer
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Abstract

A correlation was made between the severity of clinical symptoms of SLE and the results of the migration inhibitory factor (MIF) production test. For this purpose 10 patients with various manifestations of SLE were examined by MIF production test before and after the immunosuppressive therapy. A good correlation between the actual clinical stage and the results of the MIF production test was found. The successful immunosuppressive therapy turned the positive MIF production into the negative one in most of the observed patients. The MIF production test is therefore recommended as a good complementary test for the estimation of the actual state of the SLE.

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系统性红斑狼疮患者DNA迁移抑制因子产生试验结果与病情严重程度的相关性
SLE临床症状的严重程度与迁移抑制因子(MIF)产生试验结果之间存在相关性。为此,我们对10例不同表现的SLE患者在免疫抑制治疗前后进行了MIF生成试验。发现实际临床分期与MIF产生试验结果有很好的相关性。成功的免疫抑制治疗使大多数观察患者的阳性MIF产生变为阴性。因此,MIF产生试验被推荐作为估计SLE实际状态的一个很好的补充试验。
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