The methylation of DNA in regenerating rat liver.

T A Lawson
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Abstract

There was more persistent methylation of liver DNA from rats given [14C]DMN if it was given during liver regeneration, either after partial hepatectomy or a dose of CCl4 compared to otherwise untreated rats. During liver regeneration, DMN metabolism was slowed making the active metabolites available for longer.

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再生大鼠肝脏DNA甲基化。
与未治疗的大鼠相比,在肝脏再生期间给予[14C]DMN的大鼠,无论是在部分肝切除术后还是在CCl4剂量后,肝脏DNA的持续甲基化程度更高。在肝脏再生过程中,DMN代谢减慢,使活性代谢物的可用时间更长。
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