{"title":"Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.","authors":"C Witting, E Hultsch","doi":"10.1007/BF00461649","DOIUrl":null,"url":null,"abstract":"<p><strong>Unlabelled: </strong>The investigation of 400 adult mice had the objective to find out 1. The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and 2. The behavior of B- and T-lymphocytes under the influence of splenectomy.</p><p><strong>Results: </strong>1. A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%). 2. A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a decreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged. These results are discussed and compared with results of other authors.</p>","PeriodicalId":76850,"journal":{"name":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","volume":"92 3","pages":"267-74"},"PeriodicalIF":0.0000,"publicationDate":"1978-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00461649","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF00461649","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Unlabelled: The investigation of 400 adult mice had the objective to find out 1. The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and 2. The behavior of B- and T-lymphocytes under the influence of splenectomy.
Results: 1. A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%). 2. A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a decreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged. These results are discussed and compared with results of other authors.
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