Tanni Afia Zainab, Uddin Md Farid, Arafat Shohael Mahmud, Selim Shahjada, Mustari Marufa, Chowdhury MSI Tipu
{"title":"Glimepiride induced Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A case report","authors":"Tanni Afia Zainab, Uddin Md Farid, Arafat Shohael Mahmud, Selim Shahjada, Mustari Marufa, Chowdhury MSI Tipu","doi":"10.17352/2455-5282.000151","DOIUrl":null,"url":null,"abstract":"The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"47 3","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Journal of Medical and Clinical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/2455-5282.000151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is an important cause of hyponatremia in hospitalized patients and can be caused by a variety of drugs. SIADH is a recognized side effect of 1st generation sulfonylurea (Chlorpropamide) due to its effect on vasopressin secretion. Here we described a 55-year-old woman with uncontrolled type 2 diabetes on glimepiride with SIADH presenting with anorexia, asthenia, and altered mental status. After the withdrawal of glimepiride, these symptoms were improved and sodium level returned to a normal value which demand monitoring of serum sodium level during treatment with glimepiride.
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