Pub Date : 2024-07-19DOI: 10.17352/2455-5282.000181
Lecian Orchidea Maria
The Markov Models of genomic elements are newly considered. The representation of the fundamental matrix of the Markov model is newly theorised. The order of magnitude of the initial conditions for the elements of the transition probabilities is newly hypothesised. The model is compared with a sub-Hidden Markov Model of genomic events. The chosen representation of the states is newly proven to consist of an enveloping algebra. The new condition is posed on the Markovian feature of the originating chain from the study of the elements of the loci of the state space; in this case, the choice of the representation of the probability matrix is analytically spelled out, and Monte Carlo methods are not necessitated.
{"title":"Markov Models of Genomic Events","authors":"Lecian Orchidea Maria","doi":"10.17352/2455-5282.000181","DOIUrl":"https://doi.org/10.17352/2455-5282.000181","url":null,"abstract":"The Markov Models of genomic elements are newly considered. The representation of the fundamental matrix of the Markov model is newly theorised. The order of magnitude of the initial conditions for the elements of the transition probabilities is newly hypothesised. The model is compared with a sub-Hidden Markov Model of genomic events. The chosen representation of the states is newly proven to consist of an enveloping algebra. The new condition is posed on the Markovian feature of the originating chain from the study of the elements of the loci of the state space; in this case, the choice of the representation of the probability matrix is analytically spelled out, and Monte Carlo methods are not necessitated.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"11 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.17352/2455-5282.000179
Khmelinskii Igor, Stallinga Peter, Woodcock Leslie V
Background: The COVID-19 pandemic priorities have focused on prevention by detection and response. National governments’ prevention response decisions are based upon detection statistics from PCR (polymerase chain reaction) tests that are used to define numbers of (i) COVID-19 infected persons, (ii) COVID-19 hospitalisations, and (iii) COVID-19 deaths. These statistics assume a priori that PCR tests are nigh 100% true detectors of COVID-19 infections. Here we will provide an alternative interpretation, along with the compelling evidence, that false positives have distorted to some degree the statistics of the primary outbreaks, and account for almost the whole of the 2nd and subsequent apparent COVID-19 outbreak peaks in various countries. Methods: We extract from the published literature on PCR-test outcomes graphical data that reveals the evidence for a very large percentage of false positive results. We review the role of exosomes in the immune response to all respiratory viral infections and its effect on PCR tests. We hypothesise that exosomes, triggered by all viral respiratory infections, are largely responsible for positive outcomes from PCR tests for COVID-19. We test our alternative interpretation for consistency with the empirical epidemiological trends as published by the World Health Organization (WHO). The Scientific Method is used to direct our research efforts. Findings: We find that PCR testing data for the second and following waves of the COVID-19 pandemic indicate that these waves are mainly artefacts of false-positive results. We find that this interpretation provides a more consistent explanation of the known epidemiology of COVID-19 than the hitherto consensus notion of extremely contagious and rapidly mutating viruses. Interpretation: The RNA (ribonucleic acid) code detected in PCR tests, previously attributed to SARS-CoV-2, belongs instead to a respiratory-virus-induced immune system response by human cells that liberate exosomes, and that vitiate PCR test results. PCR tests have zero specificity in vivo due to the exosome RNA. PCR tests exhibit excellent specificity in vitro on pure samples of other respiratory viruses. The low success rate of vaccines in preventing COVID-19 is explained by the inexact identification of the SARS-CoV-2 RNA.
{"title":"Role of exosomes in false-positive COVID-19 PCR tests: Non-specificity of SARS-CoV-2-RNA in vivo detection explains artificial post-pandemic peaks","authors":"Khmelinskii Igor, Stallinga Peter, Woodcock Leslie V","doi":"10.17352/2455-5282.000179","DOIUrl":"https://doi.org/10.17352/2455-5282.000179","url":null,"abstract":"Background: The COVID-19 pandemic priorities have focused on prevention by detection and response. National governments’ prevention response decisions are based upon detection statistics from PCR (polymerase chain reaction) tests that are used to define numbers of (i) COVID-19 infected persons, (ii) COVID-19 hospitalisations, and (iii) COVID-19 deaths. These statistics assume a priori that PCR tests are nigh 100% true detectors of COVID-19 infections. Here we will provide an alternative interpretation, along with the compelling evidence, that false positives have distorted to some degree the statistics of the primary outbreaks, and account for almost the whole of the 2nd and subsequent apparent COVID-19 outbreak peaks in various countries. Methods: We extract from the published literature on PCR-test outcomes graphical data that reveals the evidence for a very large percentage of false positive results. We review the role of exosomes in the immune response to all respiratory viral infections and its effect on PCR tests. We hypothesise that exosomes, triggered by all viral respiratory infections, are largely responsible for positive outcomes from PCR tests for COVID-19. We test our alternative interpretation for consistency with the empirical epidemiological trends as published by the World Health Organization (WHO). The Scientific Method is used to direct our research efforts. Findings: We find that PCR testing data for the second and following waves of the COVID-19 pandemic indicate that these waves are mainly artefacts of false-positive results. We find that this interpretation provides a more consistent explanation of the known epidemiology of COVID-19 than the hitherto consensus notion of extremely contagious and rapidly mutating viruses. Interpretation: The RNA (ribonucleic acid) code detected in PCR tests, previously attributed to SARS-CoV-2, belongs instead to a respiratory-virus-induced immune system response by human cells that liberate exosomes, and that vitiate PCR test results. PCR tests have zero specificity in vivo due to the exosome RNA. PCR tests exhibit excellent specificity in vitro on pure samples of other respiratory viruses. The low success rate of vaccines in preventing COVID-19 is explained by the inexact identification of the SARS-CoV-2 RNA.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"63 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140456677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.17352/2455-5282.000178
C. Mata-Perera, JM López-Álvarez, DL Lorenzo-Villegas
Posterior Reversible Encephalopathy Syndrome (PRES) is an entity that has gained importance in recent years. The diagnosis is clinical-radiological. Clinically, the patient presents neurological alterations such as headache, decreased level of consciousness, seizures, and visual disturbances. Radiologically, it includes cerebral oedema, predominantly of the white matter of parietal-occipital regions on magnetic resonance imaging. Multiple situations can trigger this condition, including high blood pressure, immunosuppressants, steroids, and chemotherapy well-known risk factors. An early diagnosis and adequate treatment are essential to avoid the appearance of sequelae in these patients. This case consists of a patient diagnosed at 11 years of age with a bifocal non-germline tumour in the brain who, after treatment with chemotherapy, presented a clinical deterioration with instability compatible with septic shock. Subsequently, he presented a sudden alteration in the level of consciousness accompanied by hypertension and renal failure, which was suspected of PRES after a brain CT imaging test.
{"title":"Posterior Reversible Encephalitis Syndrome (PRES) in a paediatric patient in the intensive care unit","authors":"C. Mata-Perera, JM López-Álvarez, DL Lorenzo-Villegas","doi":"10.17352/2455-5282.000178","DOIUrl":"https://doi.org/10.17352/2455-5282.000178","url":null,"abstract":"Posterior Reversible Encephalopathy Syndrome (PRES) is an entity that has gained importance in recent years. The diagnosis is clinical-radiological. Clinically, the patient presents neurological alterations such as headache, decreased level of consciousness, seizures, and visual disturbances. Radiologically, it includes cerebral oedema, predominantly of the white matter of parietal-occipital regions on magnetic resonance imaging. Multiple situations can trigger this condition, including high blood pressure, immunosuppressants, steroids, and chemotherapy well-known risk factors. An early diagnosis and adequate treatment are essential to avoid the appearance of sequelae in these patients. This case consists of a patient diagnosed at 11 years of age with a bifocal non-germline tumour in the brain who, after treatment with chemotherapy, presented a clinical deterioration with instability compatible with septic shock. Subsequently, he presented a sudden alteration in the level of consciousness accompanied by hypertension and renal failure, which was suspected of PRES after a brain CT imaging test.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"56 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-02DOI: 10.17352/2455-5282.000178
C. Mata-Perera, JM López-Álvarez, DL Lorenzo-Villegas
Posterior Reversible Encephalopathy Syndrome (PRES) is an entity that has gained importance in recent years. The diagnosis is clinical-radiological. Clinically, the patient presents neurological alterations such as headache, decreased level of consciousness, seizures, and visual disturbances. Radiologically, it includes cerebral oedema, predominantly of the white matter of parietal-occipital regions on magnetic resonance imaging. Multiple situations can trigger this condition, including high blood pressure, immunosuppressants, steroids, and chemotherapy well-known risk factors. An early diagnosis and adequate treatment are essential to avoid the appearance of sequelae in these patients. This case consists of a patient diagnosed at 11 years of age with a bifocal non-germline tumour in the brain who, after treatment with chemotherapy, presented a clinical deterioration with instability compatible with septic shock. Subsequently, he presented a sudden alteration in the level of consciousness accompanied by hypertension and renal failure, which was suspected of PRES after a brain CT imaging test.
{"title":"Posterior Reversible Encephalitis Syndrome (PRES) in a paediatric patient in the intensive care unit","authors":"C. Mata-Perera, JM López-Álvarez, DL Lorenzo-Villegas","doi":"10.17352/2455-5282.000178","DOIUrl":"https://doi.org/10.17352/2455-5282.000178","url":null,"abstract":"Posterior Reversible Encephalopathy Syndrome (PRES) is an entity that has gained importance in recent years. The diagnosis is clinical-radiological. Clinically, the patient presents neurological alterations such as headache, decreased level of consciousness, seizures, and visual disturbances. Radiologically, it includes cerebral oedema, predominantly of the white matter of parietal-occipital regions on magnetic resonance imaging. Multiple situations can trigger this condition, including high blood pressure, immunosuppressants, steroids, and chemotherapy well-known risk factors. An early diagnosis and adequate treatment are essential to avoid the appearance of sequelae in these patients. This case consists of a patient diagnosed at 11 years of age with a bifocal non-germline tumour in the brain who, after treatment with chemotherapy, presented a clinical deterioration with instability compatible with septic shock. Subsequently, he presented a sudden alteration in the level of consciousness accompanied by hypertension and renal failure, which was suspected of PRES after a brain CT imaging test.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"46 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.17352/2455-5282.000177
SA Daud, OM Popoola, TO Ogunsola, AB Omotoso
The study was conducted to assess the level of adoption of improved cassava processing technologies by cassava processors in Oyo State, Nigeria. A multistage sampling technique was used to select 190 cassava processors in Oyo state. Data was collected through an interview guide while descriptive statistics was used to achieve the objectives. The mean age of the respondents was estimated at 47 years and 90.00% of the respondents were married. The mean household size and years of experience were 6 persons and 11 years respectively. The majority (64.21%) had a secondary occupation (64.21%) while 66.32% of the respondents received credit. Only 7.37% of the respondents received information from extension agents. About 92.63% get information from other sources like radio, fellow professors, friends, and relatives. The major constraints encountered by the respondents include inadequate credit facilities, inadequate extension contact high cost of cassava tubers, and high costs of hiring cassava processing machines. Therefore, extension services on improved cassava processing technologies should be intensified in the study area by offering services, especially in aspects that show low adoption in this study like the mechanical peeler and fryer.
{"title":"Does information sources improve the adoption of new technology? Evidence from cassava processing enterprise","authors":"SA Daud, OM Popoola, TO Ogunsola, AB Omotoso","doi":"10.17352/2455-5282.000177","DOIUrl":"https://doi.org/10.17352/2455-5282.000177","url":null,"abstract":"The study was conducted to assess the level of adoption of improved cassava processing technologies by cassava processors in Oyo State, Nigeria. A multistage sampling technique was used to select 190 cassava processors in Oyo state. Data was collected through an interview guide while descriptive statistics was used to achieve the objectives. The mean age of the respondents was estimated at 47 years and 90.00% of the respondents were married. The mean household size and years of experience were 6 persons and 11 years respectively. The majority (64.21%) had a secondary occupation (64.21%) while 66.32% of the respondents received credit. Only 7.37% of the respondents received information from extension agents. About 92.63% get information from other sources like radio, fellow professors, friends, and relatives. The major constraints encountered by the respondents include inadequate credit facilities, inadequate extension contact high cost of cassava tubers, and high costs of hiring cassava processing machines. Therefore, extension services on improved cassava processing technologies should be intensified in the study area by offering services, especially in aspects that show low adoption in this study like the mechanical peeler and fryer.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.17352/2455-5282.000176
Alhalabi Lutfallah, Zenati Mazen
Background: The aim of this study is to compare the effect of Bone Morphogenetic Proteins (rhBMP), carried on a gelatin sponge scaffold in comparison with the Xenograft BioOss® in the management of bone defects. Case presentation: The case is a one-year-old rabbit that had 4 identical holes 5*5 mm within the femur bone, BMP2 was placed within the first hole with a gelatin sponge, and the second defect was left empty. A gelatin sponge was placed alone within the third hole, and a BioOss® graft was placed within the last defect. The radiographic evaluation was conducted (1 and 2) months after the surgical work, and the histological assessment was conducted two months after the surgical work. Results: The results of the radiographic evaluation found that healing the BMP2 hole was better than healing in the empty and the gelatin sponge group holes. There was no big difference between the healing in the holes filled with rhBMP2 with gelatin sponge and the healing in the holes filled with BioOss®. Conclusion: The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.
{"title":"The effect of bone morphogenetic proteins BMP in comparison with A Xenograft in the management of bone defects","authors":"Alhalabi Lutfallah, Zenati Mazen","doi":"10.17352/2455-5282.000176","DOIUrl":"https://doi.org/10.17352/2455-5282.000176","url":null,"abstract":"Background: The aim of this study is to compare the effect of Bone Morphogenetic Proteins (rhBMP), carried on a gelatin sponge scaffold in comparison with the Xenograft BioOss® in the management of bone defects. Case presentation: The case is a one-year-old rabbit that had 4 identical holes 5*5 mm within the femur bone, BMP2 was placed within the first hole with a gelatin sponge, and the second defect was left empty. A gelatin sponge was placed alone within the third hole, and a BioOss® graft was placed within the last defect. The radiographic evaluation was conducted (1 and 2) months after the surgical work, and the histological assessment was conducted two months after the surgical work. Results: The results of the radiographic evaluation found that healing the BMP2 hole was better than healing in the empty and the gelatin sponge group holes. There was no big difference between the healing in the holes filled with rhBMP2 with gelatin sponge and the healing in the holes filled with BioOss®. Conclusion: The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139283004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.17352/2455-5282.000171
Youssef Ayda Aly, Nada Ayman, Elkiki Hassan Ali
The most common causes of intracranial air are head trauma and neurosurgical procedures. Less common etiologies include infection due to gas-forming organisms, mucoceles, tumors, congenital neuroenteric cysts, and dural defects. Here, we present a case of an ethmoidal sinus osteoma associated with pneumocephalus. Osteomas of the paranasal sinuses are benign, often asymptomatic, tumors that progress very slowly. Endocranial development of an osteoma can breach the dura mata, allowing air to enter the cranium producing pneumocephalia which leads to severe neurological deficiencies. Pneumocephalia is an exceptional complication of osteoma.
{"title":"Ethmoidal sinus osteoma associated with Pneumocephalus","authors":"Youssef Ayda Aly, Nada Ayman, Elkiki Hassan Ali","doi":"10.17352/2455-5282.000171","DOIUrl":"https://doi.org/10.17352/2455-5282.000171","url":null,"abstract":"The most common causes of intracranial air are head trauma and neurosurgical procedures. Less common etiologies include infection due to gas-forming organisms, mucoceles, tumors, congenital neuroenteric cysts, and dural defects. Here, we present a case of an ethmoidal sinus osteoma associated with pneumocephalus. Osteomas of the paranasal sinuses are benign, often asymptomatic, tumors that progress very slowly. Endocranial development of an osteoma can breach the dura mata, allowing air to enter the cranium producing pneumocephalia which leads to severe neurological deficiencies. Pneumocephalia is an exceptional complication of osteoma.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127975318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-21DOI: 10.17352/2455-5282.000169
Madike Reema, L. Andrew
A 79-year-old man presented with gait dyspraxia approximately 2 days after receiving the first dose of the AstraZeneca COVID-19 vaccine (AZ-COVID-19-vax). He had no previous active issues and was currently on no medications.
{"title":"A case of acute transverse myelitis following the AstraZeneca COVID-19 vaccine","authors":"Madike Reema, L. Andrew","doi":"10.17352/2455-5282.000169","DOIUrl":"https://doi.org/10.17352/2455-5282.000169","url":null,"abstract":"A 79-year-old man presented with gait dyspraxia approximately 2 days after receiving the first dose of the AstraZeneca COVID-19 vaccine (AZ-COVID-19-vax). He had no previous active issues and was currently on no medications.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131610194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-27DOI: 10.17352/2455-5282.000168
Balão Ana Beatriz, Vassão Patricia Gabrielli, de Camargo Marcela Regina, Dourado Victor Zuniga, Tucci Helga Tatiane, Muniz Rennó Ana Cláudia
Introduction: Osteoarthritis (OA) is the most common chronic condition of the joints that leads to pain, stiffness and disability. Aim: The aim of this study was to determine the effectiveness of a sensory-motor exercises program and the photobiomodulation on pain, muscle strength, severity of the injury and dynamic balance of women with knee osteoarthritis. Method and Materials: Thirty-two women were randomized in sensory-motor exercises associated with the placebo photobiomodulation group (SMAG) and sensory-motor exercises with the active photobiomodulation group (SMPG). The pain, knee flexor and extensor peak torque, severity of the injury and dynamic balance were evaluated with the numeric pain rating scale, cell roll, Knee Injury and Osteoarthritis Outcome Score and timed up and go, respectively. Subjects were administered sensory-motor exercises, strengthening exercises and photobiomodulation via cluster applied at the end of each training session for 8 weeks, 2 times/week. Results: There was no significant improvement in the knee flexor and extensor peak torque, meantime, there was a significant linear positive correlation in the sensory-motor exercises program associated with the placebo photobiomodulation group (p = 0.002) at the end of treatment. A significant improvement in the severity of injury (p = 0.002) and dynamic balance (p = < 0.001) was observed in both groups. Furthermore, the level of pain showed a significant improvement in the sensory-motor exercises program associated with the placebo photobiomodulation group (p = 0.043). Conclusion: Sensory-motor exercise program promotes beneficial effects on the severity of the injury and dynamic balance and its association with photobiomodulation was able to produce an extra effect in pain relief. However, adding photobiomodulation to routine exercise regimes for subjects with knee osteoarthritis should be investigated.
{"title":"Muscle strength, level of pain and balance in women with knee osteoarthritis after a sensory-motor exercise program associated to photobiomodulation therapy via cluster: a single-blinded randomized with placebo control trial","authors":"Balão Ana Beatriz, Vassão Patricia Gabrielli, de Camargo Marcela Regina, Dourado Victor Zuniga, Tucci Helga Tatiane, Muniz Rennó Ana Cláudia","doi":"10.17352/2455-5282.000168","DOIUrl":"https://doi.org/10.17352/2455-5282.000168","url":null,"abstract":"Introduction: Osteoarthritis (OA) is the most common chronic condition of the joints that leads to pain, stiffness and disability. Aim: The aim of this study was to determine the effectiveness of a sensory-motor exercises program and the photobiomodulation on pain, muscle strength, severity of the injury and dynamic balance of women with knee osteoarthritis. Method and Materials: Thirty-two women were randomized in sensory-motor exercises associated with the placebo photobiomodulation group (SMAG) and sensory-motor exercises with the active photobiomodulation group (SMPG). The pain, knee flexor and extensor peak torque, severity of the injury and dynamic balance were evaluated with the numeric pain rating scale, cell roll, Knee Injury and Osteoarthritis Outcome Score and timed up and go, respectively. Subjects were administered sensory-motor exercises, strengthening exercises and photobiomodulation via cluster applied at the end of each training session for 8 weeks, 2 times/week. Results: There was no significant improvement in the knee flexor and extensor peak torque, meantime, there was a significant linear positive correlation in the sensory-motor exercises program associated with the placebo photobiomodulation group (p = 0.002) at the end of treatment. A significant improvement in the severity of injury (p = 0.002) and dynamic balance (p = < 0.001) was observed in both groups. Furthermore, the level of pain showed a significant improvement in the sensory-motor exercises program associated with the placebo photobiomodulation group (p = 0.043). Conclusion: Sensory-motor exercise program promotes beneficial effects on the severity of the injury and dynamic balance and its association with photobiomodulation was able to produce an extra effect in pain relief. However, adding photobiomodulation to routine exercise regimes for subjects with knee osteoarthritis should be investigated.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"496 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116325976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-25DOI: 10.17352/2455-5282.000167
Cerci Kubra, Patir Pusem
Refractory pruritus associated with Essential Thrombocythemia (ET) is rare. Herein, we present the first report of resistant pruritus responsive to ruxolitinib in an ET patient with a calreticulin mutation.
{"title":"Ruxolitinib as a therapy choice for refractory pruritus in a patient with essential thrombocythemia with CALR mutation","authors":"Cerci Kubra, Patir Pusem","doi":"10.17352/2455-5282.000167","DOIUrl":"https://doi.org/10.17352/2455-5282.000167","url":null,"abstract":"Refractory pruritus associated with Essential Thrombocythemia (ET) is rare. Herein, we present the first report of resistant pruritus responsive to ruxolitinib in an ET patient with a calreticulin mutation.","PeriodicalId":389545,"journal":{"name":"Global Journal of Medical and Clinical Case Reports","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121735945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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