Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis

Endothelial Dysfunction - Old Concepts and New Challenges Pub Date : 2018-10-24 DOI:10.5772/INTECHOPEN.76745

Estefanía Nova-Lampeti, Valeria Aguilera, Katherine Oporto, Paula Guzmán, V. Ormazábal, F. Zúñiga, C. Escudero, C. Aguayo

{"title":"Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis","authors":"Estefanía Nova-Lampeti, Valeria Aguilera, Katherine Oporto, Paula Guzmán, V. Ormazábal, F. Zúñiga, C. Escudero, C. Aguayo","doi":"10.5772/INTECHOPEN.76745","DOIUrl":null,"url":null,"abstract":"HOX genes belong to a family of transcription factors characterized by a 183 bp DNA sequence called homeobox, which code for a 61-amino-acid domain defined as the home -odomain. These genes play a central role during embryonic development by control- ling body organization, organogenesis, and stem cell differentiation. They can also play a role in adult processes such as embryo implantation, hematopoiesis, and endothelial differentiation. Since endothelial cell differentiation is one of the main steps to initiate vasculogenesis and angiogenesis, we analyzed the role of several Hox genes in the regu- lation of these two processes. In this chapter, we summarized the evidence to support the function of Hox genes in adult tissues, specifically in endothelial cell differentiation, by studying their mechanism of action and how their target genes regulate vasculogenesis and angiogenesis. Understanding the cellular and molecular mechanisms triggered by Hox biological effects is pivotal for designing new drugs or therapies for high prevalent pathologies, such as cardiovascular diseases.","PeriodicalId":254860,"journal":{"name":"Endothelial Dysfunction - Old Concepts and New Challenges","volume":"68 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endothelial Dysfunction - Old Concepts and New Challenges","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/INTECHOPEN.76745","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 12

Abstract

HOX genes belong to a family of transcription factors characterized by a 183 bp DNA sequence called homeobox, which code for a 61-amino-acid domain defined as the home -odomain. These genes play a central role during embryonic development by control- ling body organization, organogenesis, and stem cell differentiation. They can also play a role in adult processes such as embryo implantation, hematopoiesis, and endothelial differentiation. Since endothelial cell differentiation is one of the main steps to initiate vasculogenesis and angiogenesis, we analyzed the role of several Hox genes in the regu- lation of these two processes. In this chapter, we summarized the evidence to support the function of Hox genes in adult tissues, specifically in endothelial cell differentiation, by studying their mechanism of action and how their target genes regulate vasculogenesis and angiogenesis. Understanding the cellular and molecular mechanisms triggered by Hox biological effects is pivotal for designing new drugs or therapies for high prevalent pathologies, such as cardiovascular diseases.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

成人组织中的Hox基因及其在内皮细胞分化和血管生成中的作用

HOX基因属于一个转录因子家族，其特征是一个183 bp的DNA序列，称为homeobox，它编码一个61个氨基酸的结构域，称为home -o结构域。这些基因通过控制机体组织、器官发生和干细胞分化，在胚胎发育过程中起着中心作用。它们也可以在胚胎着床、造血和内皮分化等成人过程中发挥作用。由于内皮细胞分化是启动血管生成和血管生成的主要步骤之一，我们分析了几个Hox基因在这两个过程中的调控作用。在本章中，我们通过研究Hox基因的作用机制以及它们的靶基因如何调节血管生成和血管生成，总结了支持Hox基因在成人组织中，特别是在内皮细胞分化中的功能的证据。了解由Hox生物效应引发的细胞和分子机制对于设计针对心血管疾病等高发疾病的新药或疗法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Endothelial Dysfunction - Old Concepts and New Challenges

自引率

0.00%

发文量

期刊最新文献

Hox Genes in Adult Tissues and Their Role in Endothelial Cell Differentiation and Angiogenesis Pulmonary Vascular Endothelial Cells Endothelium at a Glance Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction The Markers of Endothelial Activation