Nasolacrimal way of stem cells implantation

Abstract

Modern cell technologies quickly became the usual approach in complex treatment of patients with various diseases of the brain and spinal cord.1–4 There are systemic and local methods as the dominant ways of introducing stem cells (SC) in traumas, strokes and other destructive processes. Intravenous and intra-arterial ways of introducing SC suspension are the most popular among systemic methods.5,6 Specialists also use local methods of SC delivery to the brain, which include skull trepanation, laminectomy, and the SC introduction into cerebrospinal fluid.7,8 Additional surgical interventions (trepanation, laminectomy, suboccipital or lumbar puncture), as well as damage of significant number of SC on the way from the site of injection to the area of destruction are the disadvantages of these methods. In this regard, scientists offer alternative ways of SC introduction to the brain and spinal cord.