{"title":"Studies with the baboon endogenous virus and its pseudotype of murine sarcoma virus in marmosets.","authors":"R L Heberling, S S Kalter, J W Eichberg, B M Levy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Three marmoset species (Saguinus oedipus oedipus, S. fuscicollis, Callithrix jacchus) failed to show evidence of infection or disease following inoculation of baboon endogenous type-C virus (BaEV). Cells infected with a Kirsten murine sarcoma-BaEV pseudotype (MSV[BaEV]) produced a progressive fibrosarcoma in S. o. oedipus and tumors in S. fuscicollis and C. jacchus which regressed. Tumor formation is believed to be due to growth of inoculated, virus-infected cells and not transformation of marmoset cells. S. o. oedipus showed the best serum neutralizing antibody response to BaEV and MSV(BaEV), S. fuscicollis a moderate response and C. jacchus no response.</p>","PeriodicalId":76345,"journal":{"name":"Primates in medicine","volume":"10 ","pages":"142-8"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Primates in medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Three marmoset species (Saguinus oedipus oedipus, S. fuscicollis, Callithrix jacchus) failed to show evidence of infection or disease following inoculation of baboon endogenous type-C virus (BaEV). Cells infected with a Kirsten murine sarcoma-BaEV pseudotype (MSV[BaEV]) produced a progressive fibrosarcoma in S. o. oedipus and tumors in S. fuscicollis and C. jacchus which regressed. Tumor formation is believed to be due to growth of inoculated, virus-infected cells and not transformation of marmoset cells. S. o. oedipus showed the best serum neutralizing antibody response to BaEV and MSV(BaEV), S. fuscicollis a moderate response and C. jacchus no response.
接种狒狒内源性c型病毒(BaEV)后，三种狨猴(俄狄浦斯猴、fuscicollis猴、狐猴)均未表现出感染或发病的迹象。感染Kirsten小鼠肉瘤-BaEV假型(MSV[BaEV])的细胞在俄狄浦斯S. o. oedipus中产生进行性纤维肉瘤，在fuscicollis和C. jacchus中产生肿瘤，并退化。肿瘤的形成被认为是由于接种的病毒感染细胞的生长，而不是狨猴细胞的转化。俄狄浦斯S. o. oedipus对BaEV和MSV(BaEV)的血清中和抗体反应最好，fuscicollis有中等反应，jacchus无反应。
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