Binding of platinum to human transferrin

R. Sterjernholm , F.W. Warner , J.W. Robinson , E. Ezekiel , N. Katayam
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引用次数: 12

Abstract

A complex of platinum and human transferrin has been formed by appropriately combining apotransferrin (metal free protein) and potassiumchloroplatinate (K2PtCl4). Atomic absorption spectroscopy indicated that both primary binding sites on the protein participated in the complex. Electron paramagnetic resonance (EPR) examination showed that the bound platinum was not paramagnetic, and thus it is highly probable that the Pt ion is in the +2 oxidation state. The results suggest a possible mechanism for physiological distribution of third-transition-series metal.

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铂与人转铁蛋白的结合
转铁蛋白(无金属蛋白)与氯铂酸钾(K2PtCl4)适当结合,形成了铂与人转铁蛋白复合物。原子吸收光谱表明,蛋白质上的两个主要结合位点都参与了该复合物。电子顺磁共振(EPR)检测表明,结合的铂不具有顺磁性,因此极有可能铂离子处于+2氧化态。结果提示了第三过渡系金属生理分布的可能机制。
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