Gene MDM2 as Biomarker Proliferation of Abnormal Cells: A Review Article

Abstract

Cancer begins due to the proliferation and differentiation of normal cells into abnormal cells. This process is a change in normal cells into cancer cells. This process begins with the process of initiation, promotion and progression from normal cells to cancer cells. Under normal conditions, cell division, proliferation and differentiation are well controlled. Non-lethal genetic defects are central to carcinogenesis. Genetic damage or mutation can occur due to environmental influences such as chemicals, radi -ation, viruses or inherited in germinativum cells. These genes inhibit growth by regulating cell cycle checkpoints, called gatekeep-ers, while guardians of gene stability, protecting the genome are called caretakers. Under normal circumstances with ribosomal L5 protein, and with p300 / CBP (CREAM Binding Protein). Recently, this domain was found to contribute to p53 degradation because the mutant MDM2 from this domain was able to degrade p53.