Comparative evaluation of interleukin-6 in the liver tissues, bile duct, blood serum and urine in patients with obstructive jaundice of benign etiology

Abstract

The purpose of the study - The comparative assessment analyzes of IL-6 content in the liver tissue, serum and bile duct in the dynamics of the surgical treatment of 67 patients with obstructive jaundice. In all patients, the cause of obstructive jaundice was choledocholithiasis. Materials and metods - The degree of hepatic dysfunction was determined based on blood markers of cholestasis and cytolysis of hepatocytes. The I degree hepatic dysfunction was observed - in 21 patients, II degree hepatic dysfunction - in 14, III degree hepatic dysfunction - in 10, and IV degree hepatic dysfunction – in 9 patients. In 13 patients on the background of obstructive jaundice were observed purulent cholangitis. Results and discussion - Comparison of IL-6 in the liver tissue, ductal bile, blood, serum and urine in patients with varying degrees of hepatic dysfunction showed that serum characterized the lower their levels of this indicator than in the liver tissue, bile and urine, and most of this cytokine defi ned in bile . In the presence of purulent cholangitis greatest observed accumulation of IL-6, liver tissue, bile and urine compared to serum. Conclusion - Local and systemic levels of IL-6 may serve as markers for assessing the severity of the pathological process, conservative therapy planning, monitoring of treatment effi cacy, and clinical course. Key words obstructive jaundice, choledocholithiasis, interleukin - 6, hepatic dysfunction.