Analysis of malondialdehyde and ferric reducing ability of plasma in type 2 diabetes mellitus patients in Lucknow city, India

Mohammad Zaid Kidwai, Roshan Alam, H. Ahsan, M. Khan, Saba Khan
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Abstract

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) is increasing due to obesity and sedentary lifestyles. Increased oxidative stress leads to oxidative damage of biomolecules and decreased antioxidant capacity.Aim: The study was designed to determine the malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) in T2DM patients at IIMS&R Hospital, Lucknow.Method: The oxidative stress was analyzed in T2DM patients as MDA. The total antioxidant capacity was estimated through the FRAP in T2DM patients and control subjects.Results: The level of MDA was observed to be higher (4.84 ± 1.09) in T2DM patients compared to controls (2.20 ± 0.85). The FRAP was lower among T2DM patients (509.46 ± 126.36) compared to controls (895.62 ± 179.92). The difference between FRAP in T2DM patients and controls was statistically significant (p=0.0001).Conclusion: MDA was found to be higher in T2DM, and the FRAP level was lower in T2DM patients compared to controls, signifying increased oxidative stress and decreased antioxidant level in T2DM patients.
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印度勒克瑙市2型糖尿病患者血浆丙二醛和铁还原能力分析
背景:由于肥胖和久坐不动的生活方式,2型糖尿病(T2DM)的发病率和患病率正在上升。氧化应激增加导致生物分子氧化损伤,抗氧化能力下降。目的:研究勒克瑙IIMS&R医院T2DM患者血浆丙二醛(MDA)和铁还原能力(FRAP)。方法:采用MDA测定T2DM患者氧化应激水平。通过FRAP估计T2DM患者和对照组的总抗氧化能力。结果:T2DM组MDA水平(4.84±1.09)高于对照组(2.20±0.85)。T2DM患者的FRAP(509.46±126.36)低于对照组(895.62±179.92)。T2DM患者与对照组FRAP差异有统计学意义(p=0.0001)。结论:T2DM患者与对照组相比,MDA升高,FRAP水平降低,提示T2DM患者氧化应激升高,抗氧化水平降低。
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