The Effect of Mortality of Diabetes Tuberculosis Patients Using Meta-Analysis

Abstract

Objective: To study the mortality of tuberculosis patients with diabetes, compared to tuberculosis patients without diabetes. Design: We searched papers, including the prospective studies and retrospective studies from 1998 to 2009. All papers must relate to the studies of the mortality of tuberculosis patients with diabetes or without diabetes. Data sources: We electronically searched the register of the mortality, tuberculosis, and diabetes group from several journals. Selection of studies: More than 1000 articles we searched, including prospective studies and retrospectives studies. Only 21 papers are related to our subject. After fully screen the data of these papers, 14 papers are completely fit the conditions of our requirements. Main outcome measures: We meta-analysis the odds ratio of mortality of DMTB patients, compare to TB patients without DM. We selected random affects model to show the results of odds ratio. Results: This study shows significantly higher mortality in DMTB group. The entire odds ratio is 2.18. 95% CI= [1.50, 3.16], Z=4.09 (p<0.0001), I2=63.0% (Figure 1). Conclusion: Diabetes is one of the risk effects to the tuberculosis patients. Patients who got tuberculosis with diabetes have significantly higher mortality than tuberculosis patients without diabetes. To take care of tuberculosis patients with diabetes is much more critical.