Role of Toll-Like Receptor (TLR)-Signaling in Cancer Progression and Treatment

Cell Interaction - Molecular and Immunological Basis for Disease Management Pub Date : 2020-11-03 DOI:10.5772/intechopen.94423

S. Prasad, Rahul Kumar

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引用次数: 3

Abstract

Toll-like receptors (TLRs) are the most essential pattern recognition receptors in mediating the effects of innate immunity. It plays a pivotal role in inducing immune response against a number of pathogens, various diseases conditions including pathogenesis of cancer. Inflammation is often associated with the development and progression of most of cancer, where TLRs interplay very crucial roles. Moreover, TLRs activation can impact the initiation, progression and treatment of cancer by modulating the inflammatory microenvironment. Rapidly growing number of evidences related to TLRs function and expression in cancer cells, suggests its critical association with chemoresistance and tumourigenesis. The current chapter describes the development of various agonist and antagosist for TLRs and their application in cancer therapeutics. The aim of this book chapter is to highlights basic features of TLRs, and its role in cancer progression. It also addresses, how a defect in the TLRs signaling pathway can contributes towards carcinogenesis and recent development of cancer therapeutics that target TLR signaling pathways.

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toll样受体(TLR)信号在癌症进展和治疗中的作用

toll样受体(TLRs)是介导先天免疫的最重要的模式识别受体。它在诱导针对许多病原体的免疫反应中起着关键作用，包括癌症的发病机制。炎症通常与大多数癌症的发生和发展有关，tlr在其中起着非常关键的作用。此外，TLRs的激活可以通过调节炎症微环境影响癌症的发生、进展和治疗。越来越多的证据表明，TLRs在癌细胞中的功能和表达与化疗耐药和肿瘤发生密切相关。本章介绍了各种tlr激动剂和拮抗剂的发展及其在癌症治疗中的应用。本章的目的是强调tlr的基本特征，以及它在癌症进展中的作用。它还讨论了TLR信号通路中的缺陷如何有助于致癌，以及最近针对TLR信号通路的癌症治疗方法的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cell Interaction - Molecular and Immunological Basis for Disease Management

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