An unexpected effect of teleworking: acute clinical manifestations of a hypersensitivity pneumonitis to home parrots

Andreea Mutu, I. Belaconi, C. Toma, M. Oțelea
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Abstract

Abstract Hypersensitivity pneumonitis (HP) is a complex inflammatory and/or fibrotic immune-mediated disease that involves lung parenchyma and small airways caused by an inhaled antigen in susceptible individuals. It is currently the third most frequent interstitial lung disease (ILD) after idiopathic pulmonary fibrosis (IPF) and connective tissue disease with ILD. Diagnosis of HP is often challenging as identifying a causative agent is one of the main arguments in diagnosis along with specific serum IgG testing, suggestive HRCT and/or BAL, and in some cases histopathological findings. However, in up to 60 % of cases, exposure is not identified despite a thorough exposure history. HP is more frequent associated with occupational exposures, up to 20%, but non-occupational environmental exposure remains an important cause. We present a case of bird fancier’s lung that illustrates the challenges and the importance of identifying the culprit antigen as the elimination of exposure in combination with corticosteroids can lead to improvement in lung function, symptoms and leads to a better prognosis and may stop of evolving in sever fibrotic forms of HP.
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远程办公的意外影响:家鹦鹉过敏性肺炎的急性临床表现
摘要过敏性肺炎(Hypersensitivity pneumonitis, HP)是一种复杂的炎症性和/或纤维化性免疫介导疾病,易感个体因吸入抗原引起肺实质和小气道病变。它是目前第三常见的间质性肺疾病(ILD),仅次于特发性肺纤维化(IPF)和伴有ILD的结缔组织病。HP的诊断通常是具有挑战性的,因为确定病原体是诊断的主要论点之一,还有特异性血清IgG检测,提示HRCT和/或BAL,以及在某些情况下的组织病理学结果。然而,在高达60%的病例中,尽管有全面的接触史,但仍未发现接触。HP更常与职业暴露相关,高达20%,但非职业环境暴露仍然是一个重要原因。我们报告了一个鸟类爱好者肺的病例,说明了识别罪魁祸首抗原的挑战和重要性,因为消除暴露与皮质类固醇结合可以改善肺功能,改善症状,改善预后,并可能停止发展为严重纤维化形式的HP。
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