Special Invited Lectures: Microfabrication and Nanostructure Processing of Advanced Biological Systems

J. Ying
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Abstract

Microelectromechanical systems (MEMS) can be combined with nanostructured materials in the design of multifunctional devices. MEMS provide for the ease of microfluidics control, and allows for the full integration of mechanical and electrical components at the macroscopic level through a top-down approach. In contrast, nanostructured materials enable the bottom-up synthesis and assembly of molecular, supramolecular and nanometer-scale structures with controlled surface functionalization. By bringing together MEMS and nanostructured materials, we can achieve (i) automated preparation and manipulation of biological samples, (ii) high-throughput drug screening, (iii) ultrasensitive biomolecular sensors and medical diagnostics, (iv) complex bioreactors for cell and tissue engineering, and (v) biomimetic artificial organs and implants. This presentation describes the exciting possibilities of engineering advanced biological systems by combining microfabrication of devices and nanostructure processing of materials.
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特邀讲座:先进生物系统的微加工和纳米结构加工
微机电系统(MEMS)可以与纳米结构材料相结合来设计多功能器件。MEMS提供了微流体控制的便利性,并允许通过自上而下的方法在宏观层面上完全集成机械和电气元件。相比之下,纳米结构材料能够自下而上地合成和组装具有可控表面功能化的分子、超分子和纳米级结构。通过将MEMS和纳米结构材料结合起来,我们可以实现(i)生物样品的自动制备和操作,(ii)高通量药物筛选,(iii)超灵敏的生物分子传感器和医学诊断,(iv)用于细胞和组织工程的复杂生物反应器,以及(v)仿生人工器官和植入物。本报告描述了通过结合器件的微加工和材料的纳米结构加工,工程先进生物系统的令人兴奋的可能性。
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