A computational study of microscale flow and mass transport in vasculatized tumors

Abstract

We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding tissue (interstitial volume). A comparison of flow and mass transport in healthy and tumor tissue models is presented using four case studies with different physiological properties.