THE MATHEMATICAL MODELING OF THE EPIDEMIC DISEASES INDUCED BY BIOLOGICAL ATTACK WITH CONTAGIOUS AGENTS

V. Ordeanu, L. Ionescu
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Abstract

The current security context illustrated by the COVID-19 pandemic shows us that we have vulnerabilities, that there are threats and that there will be risks, including biological ones. In the field of BIO defense it is almost impossible to experiment at the general level. This can only be done on time in the laboratory, in vitro, in vivo and possibly in silico. The calculation methodology for the effects of possible attack with contagious biological warfare agents has certain assumptions and limitations. Considering that the population is homogeneous it results that the isolated groups, to which the infection it does not spread, will show an overestimation. Possible individual variations, particular diseases and asymptomatic cases are not taken into account so either an underestimation or an overestimation occurs. In the mathematical modeling of the epidemic diseases induced by biological attack with contagious agents can use the SEIRP model: Susceptible, Exposed and Infected, Infectious, Removed and Prophylaxis Efficacious Model. The study is important for medical operational planning.
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具有传染因子的生物攻击引起的流行病的数学建模
2019冠状病毒病大流行所反映的当前安全环境向我们表明,我们存在脆弱性,存在威胁,也将存在风险,包括生物风险。在生物防御领域,在一般水平上进行实验几乎是不可能的。这只能在实验室、体外、体内和可能的计算机中按时完成。传染性生物战剂可能攻击效果的计算方法有一定的假设和局限性。考虑到种群是同质的,其结果是,感染没有传播到的孤立群体将显示出高估。可能的个体差异、特定疾病和无症状病例没有被考虑在内,因此会出现低估或高估。在传染病病原生物攻击引起的传染病的数学建模中,可以采用SEIRP模型:易感模型、暴露感染模型、感染移除模型和预防有效模型。该研究对医疗业务规划具有重要意义。
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