Fabrication of biodegradable scaffold by powder sintering process

Abstract

To reproduce blood vessel, we proposed new process for fabricating biodegradable scaffold by powder sintering process. In this process, model for molding scaffold was materialized by rapid prototyping. Biodegradable polymer powder and porogen were dusted to model and heated. So, arbitrary shape scaffold would be fabricated. Also, porosity that influences compliance of blood vessel scaffold would be adjusted by changing ratio of the polymer powder and porogen. We studied fabrication condition of blood vessel scaffold by measuring porosity and Young's modulus when the ratio of the polymer powder and porogen was adjusted. Also, HUVECs were cultured on the scaffold, and the scaffold's biocompatibility was confirmed.