Algorithm to Quantify the Low and High Resolution HLA Matching in Renal Transplantation

Abstract

HLA matching is conventionally assessed by counting the number of MisMatches (MM) in the class I antigens and class II antigens of the donor and recipient. There is an overlap of matching scores in the MM scoring method. A numerical method has already been developed to quantify the degree of HLA matching in Low Resolution HLA matching. This study has been done to formulate an algorithm for High resolution HLA matching, with a parameter named as HLA Matching (HM) score. Mathematically, 4096 discrete values of HM score existing between 0 and 1 are obtained in 3 loci comparison for renal transplantation. Each value of HM score is unique for every possible matching combination. Donor with the highest percent HM score is considered as the best HLA matched donor. This method overcomes all the disadvantages of the conventional MM scoring method. This algorithm is useful in the donor or recipient selection and the graft survival studies.