The Role of Excipients in Liquisolid Technology

Abstract

This article gives criteria for choosing excipients in liquisolid technology. Liquisolid technology is applicable for non polar drugs by converting drug solution into dry free flowing powder. Patient compliance is more in oral route of administration .Numerous techniques like solid dispersion, micronisation, lyophilisation co-grinding, co-precipitation,complexation and nanotechnology are used to increase aqueous solubility Solid dispersion having stability issues while micronization and complexation can cause agglomeration. In Nanotechnology, high cost involved in sophicticated instruments. Liquisolid technology is considered to be one of the best technique to to overcome solubility,dissolution and bioavailability. It convert drug solution into dry free flowing powder. This technique is simple manufacturing process with low production cost. In vitro release is enhanced by using this technology. There is significant role of excipients in this novel technique to get effective release of drug. Associated problems of BCS class II and IV is mostly solved in respect to solubility. Especially carrier with high specific surface area gives good results in overcoming all challenges. Carriers such as Lactose, Starch, Avicel pH101,Fujacilin, Neusilin ,each having specific properties in release of drug. Among all mostly used carriers are Avicel, Fujacilin and Neusilin as with highest Specific Surface Area (SSA) than others. PVP and SSG is considered best disintegrating agent as having good swelling property and flow property as Polyvinypyrrolidine can be used in high dose drugs. With large SSA and high adsorptive property Neusilin, Aerosil , PVP as carrier, coating material and disintegrating agent are considered perfect excipients in liquisolid technology.